荔枝核总皂甙提取物对糖尿病小鼠的降糖疗效观察

目的 观察荔枝核总皂甙提取物对糖尿病小鼠降血糖作用。方法 采用四氧嘧啶建立糖尿病小鼠模型。从荔枝核中提取总皂甙混合物。以荔枝核总皂甙提取物为试验药、优降糖和黄连素为对照药，糖尿病小鼠经灌胃连续给药3周后测定小鼠空腹血糖值，比较不同药物降血糖效果。结果 荔枝核总皂甙提取物、优降糖和黄连素均能有效地降低糖尿病小鼠的血糖浓度（均P〈0．05），其降糖率分别为59．57％、43．64％和43．93％。荔枝核总皂甙提取物用药组糖尿病小鼠的血糖浓度明显低于糖尿病对照小鼠（P〈0．01）。荔枝核总皂甙提取物降血糖效果明显优于优降糖和黄连素（P〈0．01）。结论 荔枝核总皂甙提取物具有较强的降低糖尿病小鼠血糖功能，且其降血糖效果优于优降糖与黄连素。

Effect of total saponin extract from litchi core on the blood glucose levels of diabetic mice

Objective To determine the effect of total saponin extract from litchi core on the blood glucose levels of diabetic mice.Methods The diabetic mouse model was established by using alloxan.The diabetic mice were orally given with total saponin compound extracted from litchi core and glybenzcyclamide and berberine for three weeks.The fasting blood glucose concentrations were measured.Results The total saponin extract,glybenzcyclamide and berberine all reduced the blood glucose concentrations of diabetic mice(P<0.05),and the reduction rates were 59.57%,43.64% and 43.93%,respectively.The reduction rate of total saponin extract was significantly higher than those of glybenzcyclamide and berberine(P<0.01).Conclusion The total saponin extract from litchi core shows the powerful effect in decreasing blood glucose of diabetic mice,which is more effective than those of glybenzcyclamide and berberine.