AIDS合并马尔尼菲青霉病患者外周血Dectin-1、炎症细胞因子及CD4+T淋巴细胞表达情况及其临床意义

目的 探讨AIDS合并马尔尼菲青霉菌病(PsM)患者模式识别受体Dectin-1、炎性细胞因子及CD4+T淋巴细胞表达情况及其临床意义.方法 将120例AIDS患者根据是否合并PsM分为PsM组和非PsM组各60例,比较两组Dectin-1的平均荧光强度、CD4+T淋巴细胞计数和白细胞介素(IL)-2、IL-6、IL-12、IL-23水平.结果 PsM组的Dectin-1表达、CD4+T淋巴细胞计数、IL-2、IL-6、IL-12 和IL-23水平均低于非PsM组(P<0.05).结论 Dectin-1及其调节产生的炎症细胞因子、CD4+T水平下降可能是导致AIDS的患者对马尔尼菲青霉菌易感的重要原因.

Expressions and clinical significance of peripheral blood Dectin-1,cytokines and CD4+ T lymphocytes in patients with AIDS complicated with Penicilliosis marneffei

Objective To observe the expressions and clinical significance of pattern recognition receptor Dectin-1,cytokines and CD4+ T lymphocytes in patients with AIDS complicated with Penicilliosis marneffei(PsM).Methods A total of 120 patients with AIDS were divided into PsM group and non-PsM group depending on whether they were complicated with PsM,with 60 cases in each group.The mean fluorescence intensity of Dectin-1,CD4+ T lymphocyte count,and levels of interleukin(IL)-2,IL-6,IL-12 and IL-23 were compared between the two groups.Results The expression of Dectin-1,CD4+ T lymphocyte count,and levels of IL-2,IL-6,IL-12 and IL-23 in the PsM group were lower than those in the non-PsM group(P<0.05).Conclusion Decreasing levels of Dectin-1,cytokines subjected to the regulation of Dectin-1 and CD4+ T lymphocytes may be the importance reasons for AIDS patients who are sensitive to Penicillium marneffei.