红细胞分布宽度与结直肠癌的关系

目的 探讨红细胞分布宽度(RDW)与结直肠癌的关系.方法 选择初诊结直肠癌患者108例(结肠癌组)及健康者100例(对照组),比较两组患者的RBC、Hb、WBC、PLT及RDW水平,以及不同病理特征的结直肠癌患者的RDW水平.应用受试者工作特征(ROC)曲线分析RDW对结直肠癌的诊断价值.结果 结直肠癌组RDW及PLT水平均高于对照组(P<0.05),而RBC及Hb水平低于对照组(P<0.05),非贫血结直肠癌患者RDW水平仍高于对照组(P<0.05).浸润深度及肌层者、有脏器转移者的RDW水平分别高于浸润深度未及肌层者、无脏器转移者(P<0.05).右半结肠癌及直肠癌患者RDW水平高于左半结肠癌(P<0.05),Ⅳ期患者的RDW水平高于其他分期的患者(均P<0.05).RDW诊断结直肠癌的最佳阈值为13.22%,其ROC曲线下面积为0.653(P<0.05),敏感度和特异度分别为65.7%及63.3%.结论 RDW升高与结肠癌发生发展可能存在密切关系,RDW可能是结直肠癌早期诊断及病情判断的一个重要指标.

Relationship between red blood cell distribution width and colorectal cancer

Objective To explore the relationship between red blood cell distribution width(RDW) and colorectal cancer(CRC).Methods A total of 108 patients initially diagnosed as CRC(CRC group) and 100 healthy individuals(control group) were selected.The levels of RBC,Hb,WBC,PLT and RDW were compared between the two groups.The RDW levels were compared among the CRC patients with different pathological features.Receiver operating characteristic(ROC) curve was used to analyze the diagnostic value of RDW for CRC.Results The levels of RDW and PLT were higher but the levels of RBC and Hb were lower in the CRC group compared to the control group(P<0.05).The RDW level in the CRC patients without anemia was higher than that in the control group(P<0.05).The RDW levels of the patients with muscular layer infiltration and organ metastasis were higher than those of the patients without muscular layer infiltration and organ metastasis respectively(P<0.05).The RDW levels in the patients with right colon cancer and rectal cancer were higher than the level in the patients with left colon cancer(P<0.05).The RDW level in the patients with stage Ⅳ CRC was higher than that in the patients with the other stages(P<0.05).The optimum cutoff value of RDW for diagnosing CRC was 13.22% and the area under the ROC curve was 0.653(P<0.05),and the sensitivity and specificity were 65.7% and 63.3% respectively.Conclusion Elevated RDW might closely correlate with the incidence and development of CRC,and RDW might be an important indicator for early diagnosis and severity evaluation of CRC.