p28GANK蛋白在肝细胞性肝癌组织中的表达及其临床意义 |
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引用本文: | 莫瑞祥,杨威,李西融,廖文胜,张慧明,陈泽峰,黄芳.p28GANK蛋白在肝细胞性肝癌组织中的表达及其临床意义[J].广西医学,2016(7):919-921. |
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作者姓名: | 莫瑞祥 杨威 李西融 廖文胜 张慧明 陈泽峰 黄芳 |
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作者单位: | 1. 广西壮族自治区南溪山医院 外一科,桂林市,541002;2. 广西壮族自治区南溪山医院 病理科,桂林市,541002 |
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基金项目: | 广西医疗卫生重点科研课题(重2012014) |
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摘 要: | 目的:探讨p28GANK蛋白在肝细胞性肝癌(HCC)组织中的表达及其临床意义。方法收集HCC组织及其相应癌旁组织60例(其中32例伴有肝硬化组织)、正常肝组织30例,采用免疫组化法检测HCC、癌旁组织、肝硬化组织、正常肝组织组织中p28GANK蛋白的表达,分析p28GANK蛋白表达水平与HCC患者临床病理特征关系。结果 p28GANK蛋白在HCC、癌旁肝组织、肝硬化组织性、正常肝组织阳性表达率分别为71.7%、10.0%、12.5%、6.7%,HCC中p28GANK蛋白的阳性表达率高于其他组织(P<0.05)。 HCC患者中,低分化(Ⅲ~Ⅳ级)、淋巴结和(或)远处转移及TNM分期Ⅲ+Ⅳ者p28GANK蛋白表达阳性率分别高于高分化(Ⅰ~Ⅱ级)、无淋巴结和(或)远处转移、TNM分期Ⅰ+Ⅱ者(P<0.05)。结论 p28GANK蛋白表达可能与HCC的发生发展有关,p28GANK可作为HCC诊断的分子标志物。
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关 键 词: | 肝肿瘤 p28GANK基因 蛋白 |
Expression of p28GANK protein in hepatocellular carcinoma tissues and its clinical significance |
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Abstract: | Objective To explore the expression of p28GANK protein in hepatocellular carcinoma (HCC) tissues and its clinical significance .Methods Sixty specimens of HCC tissues and matched para-carcinoma tissues ( 32 of which contained hepatocirrhosis ) ,30 specimens of normal liver tissues were collected .Immunohistochemistry was used to detect the protein expression of p 28GANK in HCC tissues,para-carcinoma tissues,hepatocirrhosis tissues and normal liver tissues .The relationship between the expression level of p 28GANK protein and clonicopathological features of patients with HCC was analyzed .Results The positive expression rates of p 28 GANK protein in HCC tissues,para-carcinoma tissues,hepatocirrhosis tissues and normal liver tissues were 71.7%,10.0%,12.5%,6.7%,respectively. The positive expression rate of p28GANK protein in HCC tissues was significantly higher than that in the other tissues (P<0.05).In the patients with HCC,the positive expression rates of p28GANK protein in the patients with poorly differentiated type (Class Ⅲ-Ⅳ),with lymphatic/distant metastasis ,and with TNM stageⅢ+Ⅳwere higher than those in the patients with well differentiated type ( ClassⅠ-Ⅱ) , without lymphatic/distant metastasis,and with TNM stage Ⅰ+Ⅱ respectively(P<0.05).Conclusion The expression of p28GANK protein might be associated with tumorigenesis and progress of HCC .And p28 GANK may become a molecular marker for the diagnosis of HCC. |
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Keywords: | Liver neoplasms p28GANK gene Protein |
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