急诊经皮冠状动脉介入治疗对急性心肌梗死患者N末端B型利钠肽原及左心室重构的影响

目的：探讨急诊经皮冠状动脉介入（PCI）治疗对急性心肌梗死（AMI）患者N末端B型利钠肽原（NT-proBNP）及左心室重构的影响。方法将69例AMI患者随机分为观察组36例和对照组33例，观察组进行PCI治疗，对照组给予常规药物治疗。测定两组患者治疗前24 h、治疗后24 h及48 h血浆NT-proBNP水平及左室收缩末期内径（ LVESD）、左室舒张末期内径（LVEDD）、左心室射血分数（LVEF）。结果治疗后观察组血浆 NT-proBNP 水平均低于对照组（P ＜0．05），两组NT-proBNP水平均随治疗时间而呈下降趋势（P＜0．05）。两组LVESD、LVEDD、LVEF比较，差异均无统计学意义（P＞0．05）；两组LVESD、LVEDD均随治疗时间延长而下降（P＜0．05），LVEF均随治疗时间延长而上升（P＜0．05）。结论急诊PCI可显著降低AMI患者血浆NT-proBNP含量，改善左心室功能。

Effect of emergency percutaneous coronary intervention on N-terminal pro-B-type natriuretic peptide and left ventricle remodeling in patients with acute myocardial infarction

Objective To investigate the effect of emergency percutaneous coronary intervention ( PCI) on N-terminal pro-B-type natriuretic peptide(NT-proBNP) and left ventricular remodeling in patients with acute myocardial infarction (AMI).Methods Sixty-nine patients with AMI were randomly divided into observation group (n=36) or control group(n=33).The observation group was treated with PCI,while the control group was treated with routine drug therapy .Plasma NT-proBNP level, left ventricular end systolic diameter (LVESD),left ventricular end diastolic diameter(LVEDD),and left ventricular ejection fraction(LVEF) were measured in both groups 24 hours before treatment,24 and 48 hours after treatment.Results After treatment,plasma NT-proBNP level in the observation group was significantly lower than that in the control group (P<0.05),and it tended to decrease with the time of therapy in both groups (P<0.05). There were no statistical differences in LVESD ,LVEDD,or LVEF between the two groups (P>0.05),but both LVESD and LVEDD in the two groups decreased with the increase of the time of therapy (P<0.05),while LVEF in the two groups increased with the increase of the time of therapy(P<0.05).Conclusion Emergency PCI can significantly reduce the content of NT-proBNP,and improve the left ventricular function in patients with AMI .