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| 轮叶党参乙醇提取物益气活血化瘀及抗衰老作用的初步研究 | |
| 引用本文： | 徐勤,陈晓军,刘布鸣,杨平,白先群,邓立东,陈学芬.轮叶党参乙醇提取物益气活血化瘀及抗衰老作用的初步研究[J].广西医学,2008,30(12):1834-1837. |
| 作者姓名： | 徐勤 陈晓军 刘布鸣 杨平 白先群 邓立东 陈学芬 |
| 作者单位： | 1. 桂林医学院药学院,桂林市,541004 2. 广西中医药研究院,南宁市,530022 3. 桂林医学院基础医学院,桂林市,541004 4. 桂林医学院附院药剂科,桂林市,541001 |
| 基金项目： | 广西自然科学基金资助课题 |
| 摘 要： | 目的 探讨轮叶党参乙醇提取物对大鼠益气活血化瘀作用及对小鼠的抗衰老作用.方法 观察轮叶党参乙醇提取物对气虚型血瘀证模型大鼠血液流变学各项指标的影响,同时测定小鼠爬杆时闻,常压耐缺氧时间,免疫器官的重量等试验指标从而初步判断该药是否具有抗衰老作用.结果 轮叶党参乙醇提取物可明显降低气虚型血瘀证模型大鼠的全血黏度(高切、中切、低切)、血浆黏度,明显降低红细胞聚集指数,加快红细胞电泳时间,降低红细胞压积.轮叶党参乙醇提取物高荆量组在对小鼠灌胃给药后第7天、第14天能非常显著延长小鼠的常压耐缺氧时间,低剂量组在给药后第14天显著地延长小鼠的常压耐缺氧时间.该药高、低剂量组在给药后第7天、第14天均能显著增加小鼠的胸腺重量,在给药后第14天显著地增加小鼠的脾脏重量.结论 轮叶党参乙醇提取物具有益气活血化瘀作用及对小鼠有抗衰老作用. |
| 关 键 词： | 轮叶党参 乙醇提取物 益气活血化瘀 抗衰老 小鼠爬杆实验 耐缺氧实验 免疫器官 血液流变学 |
Studies on invigorating energy,activating blood flow,resolving blood stasis and anti-aging actions of alcohol extracts of Codonopsis Lanccolata |
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| XU Qin,CHEN Xiao-jun,LIU Bu-ming,YANG Ping,Bai Xian-qun,Deng Li-dong,CHEN Xue-fen.Studies on invigorating energy,activating blood flow,resolving blood stasis and anti-aging actions of alcohol extracts of Codonopsis Lanccolata[J].Guangxi Medical Journal,2008,30(12):1834-1837. | |
| Authors: | XU Qin CHEN Xiao-jun LIU Bu-ming YANG Ping Bai Xian-qun Deng Li-dong CHEN Xue-fen |
| Institution: | XU Qin,CHEN Xiao-jun,LIU Bu-ming,YANG Ping,Bai Xian-qun,Deng Li-dong,CHEN Xue-fen(1 Department of Pharmaceutical Analysis,Guilin Medical College,Guilin 541004,China,2 Department of basic medical science,3 Guangxi Institute of Traditional Medical , Pharmaceutical Sciences,Nanning 530022,4 Department of Pharmacy,Guilin Medical College Affiliated Hospital,Guilin 541001,China) |
| Abstract: | Objective To study the effects of invigorating energy,activating blood flow,resolving blood stasis and anti-aging of alcohol extract of Codonopsis lanccolata in rats and mice.Methods Each item of hemorheology of alcohol extract of Codonopsis lanccolata on animal model of Qi-deficiency and blood stasis syndrome in rats was observed.The time of pole-climbing,the time of antianoxia,weights of immune organs(thymus and spleen) on the 7th day and 14th day after gavaged with the extract for 14 days were measured.R... |
| Keywords: | Codonopsis lanccolata Alcohol extract Invigorating energy Activating blood flow Resolving blood stasis Anti-aging Pole-climbing Antianoxia Immune organs |
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