坏死性小肠结肠炎新生儿预后的影响因素

目的 探讨影响坏死性小肠结肠炎(NEC)新生儿预后的因素.方法 选取NEC患儿204例,根据治疗结局分为治愈组118例和恶化组86例,比较两组患儿一般情况、喂养情况、临床表现,分析影响NEC预后的因素.结果 代谢性酸中毒、微循环灌注不良、NEC分期、呼吸衰竭、气腹征是NEC预后的危险因素(均P<0.05),经口喂养时间晚、静脉营养及非营养性吸吮是NEC患儿预后的保护因素(P<0.05).结论 纠正代谢性酸中毒、微循环灌注不良、呼吸衰竭和气腹征,并采取静脉营养、晚开奶、非营养性吮吸或许能改善NEC预后.

Influencing factors of prognosis of neonatal necrotizing enterocolitis

Objective To explore the factors influencing the prognosis of neonatal necrotizing enterocolitis(NEC).Methods A total of 204 neonates with NEC were divided into recovery group(n=118) and deterioration group(n=86) according to the therapeutic outcome.The general situation,feeding and clinical manifestations were compared between the two groups,and the factors influencing the prognosis of NEC were analyzed.Results Metabolic acidosis,poor mircocirculation perfusion,NEC staging,respiratory failure and pneumoperitoneum sign were the risk factors for the prognosis of NEC(all P<0.05).The prolonged oral feeding,intravenous nutrition and non-nutritive sucking training were the protective factors for the prognosis of NEC(P<0.05).Conclusion Metabolic acidosis,poor mircocirculation perfusion,respiratory failure and pneumoperitoneum sign were the risk factors for the prognosis of NEC(all P<0.05).The intravenous nutrition,prolonged oral feeding and non-nutritive sucking training might improve the prognosis of NEC(P<0.05).