| 柴胡皂甙调节猫睡眠节律电活动机理的初探 |
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| 引用本文： | 孙兵,郝洪谦.柴胡皂甙调节猫睡眠节律电活动机理的初探[J].天津医科大学学报,2000,6(3):274-276. |
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| 作者姓名： | 孙兵 郝洪谦 |
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| 作者单位： | 孙兵（天津医科大学生理教研室）;郝洪谦（天津医科大学生理教研室）;郑开俊（天津医科大学生理教研室）;徐淑梅（天津医科大学生理教研室）;张际国（天津医科大学生理教研室） |
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| 基金项目： | 天津医科大学科研基金项目(ky296) |
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| 摘 要： | 目的：探讨柴胡皂甙调节猫睡眠节律活动的机理，揭示中药的的药理学作用。方法：给猫侧脑室注射色氨酸羟化酶抑制剂对氯苯丙氨酸（ＰＣＰＡ）５０ｕｌ（０．１ｍｍｏｌ／Ｌ），以猫睡眠节律电活动为指标。用睡眠多导仪连续纪录６ｈ。结果：发现ＰＣＰＡ可造成猫睡眠剥夺状态。腹腔注射柴胡皂甙可地抗和翻转ＰＣＰＡ所致的睡眠剥夺。结论：柴胡皂甙的致眠作用。可以与脑内的５－羟色氨（５－ＨＴ）的浓度变化有关，本实验为中草药的临
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| 关 键 词： | 对氯苯丙氨酸 柴胡皂甙 睡眠剥夺 |
| 文章编号： | 1006-8147(2000)03-274-03 |
| 修稿时间： | 1999年12月21 |
Preliminary study on mechanism of saikosaponins in regulating sleep rhythmical electrical activities in cat |
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| SUN Bing,HAO Hong-qian,ZHENG Kai-jun,XU Shu-mei,ZHANG Ji-guo.Preliminary study on mechanism of saikosaponins in regulating sleep rhythmical electrical activities in cat[J].Journal of Tianjin Medical University,2000,6(3):274-276. |
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| Authors: | SUN Bing HAO Hong-qian ZHENG Kai-jun XU Shu-mei ZHANG Ji-guo |
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| Institution: | Department of physiology Tianjin Medical University |
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| Abstract: | Objective:In order to study the mechanism on regulatory of saikosaponins on rhythmical electric activities of sleep in Cat. Methods: The effects of intracerebroventricular(ICV) injection of parachorophenylalainine(PCPA - inhibitor of tryptophan hydroxylase) 50μl(0.1mmol/L) on sleep(SWS Ⅰ, SWS Ⅱ and PS) were investigated in cat and by rhythmic electrical activities of sleep in cat were used as indicator. Results: Deprivation of sleep can be found in cat resulted by PCPA during six hours consecutive recording. But simultaneous peritoneal cavity injection of saikosaponins 1.5ml/kg in cat can antgaonize and turnover deprivation of sleep caused by PCPA. Conclusion:It is supposed that effects on sleep caused by saikosaponins may be relative with concentration changes of 5 - HT in the brain. |
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| Keywords: | PCPA deprivation of sleep saikosaponins |
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