FMNL2在胃癌组织中的表达及其临床意义

目的:研究在胃癌组织中形成素样蛋白2（FMNL2）的表达及临床意义。方法:收集普外科30例胃癌组织标本及其对应的远癌组织，利用免疫组化法及实时定量PCR法检测胃癌中FMNL2蛋白及mRNA的表达情况，并分析其蛋白表达与临床病理因素之间的关系，运用数据库Kaplan-Meier分析胃癌的生存状况。结果:胃癌组织中FMNL2蛋白及mRNA的表达均明显高于对应的远癌组织（均P < 0.05）；FMNL2蛋白表达与胃癌的淋巴结转移、TNM分期密切相关（均P < 0.05）,而与患者的年龄、性别、浸润深度、分化程度以及远处转移之间没有显著相关性（均P>0.05）；K-M生存曲线显示FMNL2表达水平与胃癌生存预后明显相关（均P < 0.05）。结论:FMNL2在胃癌组织中高表达，且与肿瘤的一些临床病理因素特别是淋巴结转移密切相关。FMNL2可能作为肿瘤转移、判断预后的标志基因。

Expression and clinical significance of FMNL2 in gastric cancer

Objective: To study the expression and clinical significance of Formin-like2（FMNL2） in gastric cancer tissues. Methods: Thirty gastric cancer tissue samples and their corresponding distal cancerous tissues were collected from the Department of General Surgery. The protein and mRNA expression of FMNL2 in gastric cancer and their corresponding adjacent tissues were detected by immunohistochemistry and real-time quantitative PCR, and the relationship between its protein expression and clinicopathological factors was analyzed. Survival analysis of gastric cancer was performed by Kaplan-Meier database. Results: The protein and mRNA expression of FMNL2 in gastric cancer tissues were significantly higher than those in the corresponding distal cancerous tissues(both P < 0.05). The protein expression of FMNL2 was closely correlated with lymph node metastasis and TNM stage of gastric cancer (both P < 0.05), but there was no significant correlation between expression of FMNL2 protein and age, gender, invasion depth, differentiation degree and distant metastasis(all P > 0.05). The K-M survival curve showed that the expression level of FMNL2 was significantly correlated with the survival prognosis of gastric cancer (all P < 0.05). Conclusion: FMNL2 is highly expressed in gastric cancer tissues and closely related to the clinicopathological factors of tumor, especially lymph node metastasis. FMNL2, as a target gene, may play an important role in tumor metastasis and prognosis.