| 不同促渗剂对秦皮甲素乳膏透皮吸收的影响 |
| |
| 引用本文： | 王丽峰,张思培,王阳,王艳.不同促渗剂对秦皮甲素乳膏透皮吸收的影响[J].天津医科大学学报,2014(4):320-322. |
| |
| 作者姓名： | 王丽峰 张思培 王阳 王艳 |
| |
| 作者单位： | [1]天津中医药大学实验教学部,天津300193 [2]天津中医药大学中药学院,天津300193 |
| |
| 基金项目： | 天津市科技支撑计划项目资助（10ZCZDSY12400） |
| |
| 摘 要： | 目的：制备秦皮甲素乳膏，并通过动物离体透皮吸收实验，选择秦皮甲素乳膏中最佳透皮吸收促渗剂。方法：采用透皮扩散装置，以生理盐水为接收介质，以小鼠离体腹部皮肤为透皮屏障，优选出最佳的透皮吸收促渗剂。结果：最优的透皮吸收促渗剂为5％冰片，最佳处方的动力学方程为：y=0．668x＋1．8256，r=0.9991。结论：5％的冰片作为秦皮甲素乳膏的透皮吸收促渗剂具有良好的效果。
|
| 关 键 词： | 秦皮甲素 乳膏 促渗剂 透皮吸收 小鼠 |
Effects of different types of penetration enhancers on percutaneous absorption of aesculin cream |
| |
| WANG Li-feng,ZHANG Si-pei,WANG Yan.Effects of different types of penetration enhancers on percutaneous absorption of aesculin cream[J].Journal of Tianjin Medical University,2014(4):320-322. |
| |
| Authors: | WANG Li-feng ZHANG Si-pei WANG Yan |
| |
| Institution: | g, WANG Yan (1. Experiment Teaching Center;2. School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China) |
| |
| Abstract: | Objective： To prepare aesculin cream and to study the effect of four types of penetration enhancers on percutaneous absorption of aesculin across mice skin. Methods： Diffusion cell method was applied to investigate transdermal absorption behavior of the aescuhn cream using isolated mouse skin as barrier to determine the best penetration enhancer. Results： Optimal penetration enhancer was the 5% borneo1. The dynamic equation of the best formulation was y=0.668x＋1.825 6, r=0.999 1. Conclusion： 5% borneol as aesculin cream penetration enhancer is the best. |
| |
| Keywords: | aesculin cream penetration enhancer percutaneous absorption mice |
| 本文献已被 维普 等数据库收录！ |
