合并症对局限性或局部晚期前列腺癌患者早期生存的影响

目的：应用Charlson合并症指数（CCI）,探讨合并症对局限性或局部晚期前列腺癌患者早期生存（3年内）的影响,以期提高对合并症治疗的重视。方法：回顾分析198例局限性或局部晚期前列腺癌患者的临床资料,年龄52-83岁,平均年龄71岁。随访生存情况,分析患者的年龄、合并症情况（CCI）、TNM分期、Gleason评分、病理类型、治疗方式及用药信息等因素对患者早期生存的影响,并比较分析患者生存期之间的差异。结果：在前列腺癌确诊后的第3年,3例（1.51%）患者死于前列腺癌进展发生的远处转移,7例（3.53%）患者死于非癌症相关的其他原因（CCI≥2）。生存分析结果显示,年龄、合并症、用药信息与早期生存相关,CCI≥2的患者中位生存期为26个月。结论：多种因素影响局限性或局部晚期前列腺癌患者的生存与预后,其中合并症是影响患者早期生存的独立因素,积极治疗前列腺癌患者并存的合并症,可能会获得较好的预后。

Influence of complications on early survival of patients with localized or locally advanced prostate cancer

Objective： To explore the influence of complications on early survival （in 3 years） of patients with localized or locally advanced prostate cancer to enhance public awareness on the therapy of comorbidity. Methods： Clinical data of 198 patients with localized or locally advanced prostate cancer were retrospectively analyzed ,with the patients＇ age from 52 to 83 and the average being 71. Following-up survival situation was carried out, to study the impact on early survival and compare survival differences, the author made an analysis of various factors, including： age, reasons for treatment, comorbidity, TNM stage, Gleason score, pathological type, therapy , medication information and so on. Results： In the third year after diagnosis, three patients （1.51%） died from prostate cancer metastasis and seven patients （3.53%） died because of other causes which were not related to prostate cancer. The results of single factor analysis showed that age, complication, medication information were related to early survival. Furthermore, the median survival time of patients with Charlson comorbidity index （CCI） ≥2 was 26 months. Conclusion： Many factors can affect early survival of patients with localized or locally advanced prostate cancer.Complications are independent factors affecting early survival patients. Active treatment of complications in prostate cancer patients may achieve good prognosis results.