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| APE1、VEGF在非小细胞肺癌组织中的表达及其与预后的关系 | |
| 引用本文： | 沈春燕,穆海玉,王忱,多健,佟仲生.APE1、VEGF在非小细胞肺癌组织中的表达及其与预后的关系[J].天津医科大学学报,2011,17(2):166-169,193. |
| 作者姓名： | 沈春燕 穆海玉 王忱 多健 佟仲生 |
| 作者单位： | 1. 天津医科大学研究生院,天津300070;武警医学院附属医院肿瘤科,天津300162 2. 武警医学院附属医院肿瘤科,天津,300162 3. 天津医科大学肿瘤医院,天津市肿瘤防治重点实验室,天津300060 |
| 基金项目： | 天津市应用基础及前沿技术研究计划项目 |
| 摘 要： | 目的：探讨非小细胞肺癌（NSCLC）组织中脱嘌呤/脱嘧啶核酸内切酶1（APE1/ref-1）和血管内皮生长因子（VEGF）的表达特点及其与预后的关系。方法：采用免疫组化法检测78例NSCLC组织中APE1、VEGF的表达情况,血管内皮特异标记物CD34标记并计数肿瘤微血管密度（MVD）,分析APE1、VEGF与MVD之间的关系,并结合患者的临床病理特征进行生存分析。结果：APE1、VEGF在NSCLC中的高表达率分别为78.2%和64.1%。APE1表达与吸烟、淋巴结转移密切相关,VEGF表达则与肿瘤大小、分化程度和淋巴结转移密切相关,MVD值与肿瘤大小和淋巴结转移密切相关（P〈0.05）。APE1表达与VEGF表达及MVD计数分别呈正相关（P〈0.05）。APE1、VEGF表达与患者生存期密切相关（P〈0.01）。多因素分析显示,APE1表达是影响NSCLC患者生存率的独立危险因素。结论：NSCLC组织中APE1表达与VEGF表达存在相关性,APE1过表达可能促进肿瘤血管生成,并与NSCLC患者的预后相关。 |
| 关 键 词： | 非小细胞肺癌 脱嘌呤/脱嘧啶核酸内切酶1 血管内皮生长因子 微血管密度 预后 |
APE1 and VEGF expression in non-small cell lung cancer and its relationship with prognosis |
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| SHEN Chun-yan,MU Hai-yu,WANG Chen,DUO Jian,TONG Zhong-sheng.APE1 and VEGF expression in non-small cell lung cancer and its relationship with prognosis[J].Journal of Tianjin Medical University,2011,17(2):166-169,193. | |
| Authors: | SHEN Chun-yan MU Hai-yu WANG Chen DUO Jian TONG Zhong-sheng |
| Institution: | SHEN Chun-yan1,2,MU Hai-yu2,WANG Chen3,DUO Jian3,TONG Zhong-sheng3(1.Graduate School,Tianjin Medical University,Tianjin 300070,China,2.Department of Medical Oncology,The Affiliated Hospital of Armed Police Medical College,Tianjin 300162,3.Cancer Hospital,Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China) |
| Abstract: | Objective: To evaluate the prognostic value of Apurinic/Apyrimidinic Endonuclease 1(APE1) in patients with non-small cell lung cancer(NSCLC),and study the features of APE1 expression and its correlation with vascular endothelial growth factor(VEGF) expression.Methods: Expression of APE1 and VEGF was detected by immuno-histochemical technique.MVD was evaluated by immuno-histochemistry with anti-human CD34 antibody.The relationship between APE1,VEGF and MVD was analyzed,and the results with relevant clinical ... |
| Keywords: | Non small cell lung cancer Apurinic/Apyrimidinic Endonuclease 1 Vascular endothelial growth factor Microvessel density Prognosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |