| 阿托伐他汀对急性冠状动脉综合征病人炎症因子影响 |
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| 引用本文： | 郑婕,田建会,丁思华.阿托伐他汀对急性冠状动脉综合征病人炎症因子影响[J].青岛大学医学院学报,2008,44(2):153-155. |
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| 作者姓名： | 郑婕 田建会 丁思华 |
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| 作者单位： | 1. 青岛大学医学院附属医院心内科,山东,青岛,266021
2. 青岛市第八人民医院 |
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| 摘 要： | 目的 探讨阿托伐他汀对急性冠状动脉综合征病人血清白细胞介素-18(IL-18)、高敏C-反应蛋白(hs-CRP)的影响.方法 选取在我院心内科住院的不稳定型心绞痛病人30例,稳定型心绞痛病人20例,以20例健康人作为正常对照组,分别测定其血脂、IL-18和hs-CRP水平.不稳定型心绞痛组入院后每晚给予阿托伐他汀20 mg,每日1次,共用药6周,测定治疗后病人血脂、IL-18和hs-CRP水平.结果 正常对照组、稳定型心绞痛组和不稳定型心绞痛组的血清IL-18和hs-CRP水平差别有统计学意义(F=190.961、22.359,P<0.01),不稳定型心绞痛组高于稳定型心绞痛组和对照组,稳定型心绞痛组高于对照组.不稳定型心绞痛组治疗后IL-18和hs-CRP水平均明显下降,差异有统计学意义(t=12.553、7.991,P<0.01).结论 IL-18和hs-CRP是反映冠状动脉粥样硬化病变炎症反应的重要指标;阿托伐他汀能降低急性冠状动脉综合征病人的炎症反应.
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| 关 键 词： | 冠状动脉综合征 白细胞介素-18 C反应蛋白质 阿托伐他汀 |
| 文章编号： | 1672-4488(2008)02-0153-03 |
| 修稿时间： | 2007年7月11日 |
EFFECT OF ATORVASTATIN ON PLASMA INFLAMMATION FACTOR LEVELS IN PATIENTS WITH ACUTE CORONARY SYNDROME |
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| ZHENG JIE,TIAN JIAN-HUI,DING SI-HUA.EFFECT OF ATORVASTATIN ON PLASMA INFLAMMATION FACTOR LEVELS IN PATIENTS WITH ACUTE CORONARY SYNDROME[J].Acta Academiae Medicinae Qingdao Universitatis,2008,44(2):153-155. |
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| Authors: | ZHENG JIE TIAN JIAN-HUI DING SI-HUA |
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| Institution: | ZHENG JIE,TIAN JIAN-HUI,DING SI-HUA (Department of Cardiology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266021,China) |
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| Abstract: | Objective To study the effect of atorvastatin on plasma interleukin-18(IL-18) and high sensitivity C-creactive protein(hs-CRP) levels in patients with acute coronary syndrome(ACS). Methods Patients with unstable angina(30 cases) and stable angina(20 cases) hospitalized in Department of Cardiology of our hospital were included in this study,20 normal people served as controls.Those with unstable angina were given atorvastatin(20 mg per night) for six weeks.Levels of IL-18,and hs-CRP were measured. Results Th... |
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| Keywords: | Coronary syndrome Interleukinn-18 C-reactive protein Atorvastatin |
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