不稳定型心绞痛病人血清载脂蛋白A、B与冠状动脉造影血管病变的关系

①目的探讨不稳定型心绞痛病人血清载脂蛋白A、B（apoA、apoB）及相关脂类，抗凝、纤溶指标与冠状动脉病变的关系。②方法选择行冠状动脉造影病人173例，其中不稳定型心绞痛病人136例，均经冠状动脉造影证实至少一支冠状动脉狭窄〉70％，其中单支病变65例，双支或多支病变71例，冠状动脉造影正常者（对照组）37例。采空腹静脉血2mL检测生化全套。③结果对照组、单支病变组、多支病变组apoB、三酰甘油（TG）、总胆固醇（TC）、抗凝血酶Ⅲ、纤维结合蛋白水平及apoB／apoA比较有显著统计学意义（F=3．70～6．08，P〈0．05）；而apoA1、纤溶酶原各组间差异无显著性（F=0．09、2．78，P〉0．05）。apoB、TG、纤溶酶原、纤维结合蛋白含量及apoB／apoA与冠状动脉积分呈正相关（r=0．502～0．605，P〈0．05），apoA1与冠状动脉积分呈负相关（r=-0．601，P〈0．01）。④结论apoB、apoB／apoA的升高是冠心病的危险因素，并与冠状动脉病变的严重程度有关。

CORRELATION BETWEEN SERUM APOLIPOPROTEIN A and B AND THE SEVERITY OF CORONARY ARTERIOPATHY

Objective To investigate the relationship between coronary arteriopathy and serum relative markers including apoA, apoB, other related lipids, antithrombin , profibrinolysin and fibronectin in unstable angina patients. Methods One hundred and seventy-three patients were divided into unstable angina group (n=136) and control group (n=37) by coronary arteriography. The unstable angina patients who had one or more coronary obstructions greater than 70% were sub-divided into a single-vascular lesion group (n=65) and a multiple-vascular lesion group (n=71). All blood samples were taken after fasting and then serum relative markers were determined. Results There were significant differences in apoB, TG, TC, Antithrombin , fibronectin and apoB/apoA among the three groups (F=3.70-6.08,P<0.05) but not in apoA1 and profibrinolysin (F=( 0.09), 2.78;(P>)0.05). ApoB, apoB/apoA, TG, profibrinolysin and fibronectin were positively correlated with coronary artery stenosis scores ((r=)0.502-0.605, P<0.05) while apoA1 was negatively correlated (r=-0.601, P<0.01). Conclusion The increase of apoB and apoB/apoA is one of the risk factors of CHD, and is related to the severity of CHD.