| 宫颈癌组织SLeX、CD44v6和E-Cad表达及其临床意义 |
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| 引用本文： | 谷化平.宫颈癌组织SLeX、CD44v6和E-Cad表达及其临床意义[J].青岛大学医学院学报,2010,46(1):10-12. |
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| 作者姓名： | 谷化平 |
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| 作者单位： | 中国人民解放军第251医院病理科,河北,张家口,075000 |
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| 摘 要： | 目的探讨细胞黏附分子唾液酸化路易斯-X(SLeX)抗原、CD44v6和E-钙黏附素(E-Cad)在浸润性宫颈鳞癌(ICC)中的表达及其临床意义。方法应用免疫组织化学方法,检测60例ICC组织和20例慢性宫颈炎(CCV)组织中SLeX、CD44v6和E-Cad蛋白的表达水平,并结合临床病理特征进行分析。结果ICC组织中SLeX、CD44v6和E-Cad蛋白阳性表达率分别为60.0%(36/60)、66.7%(40/60)和45.0%(27/60)。ICC组织SLeX及CD44v6阳性表达率均显著高于CCV组织(2χ=18.11、10.58,P<0.05),而E-Cad阳性表达率显著低于CCV组织(2χ=15.11,P<0.05)。ICC组织SLeX和CD44v6高表达及E-Cad低表达与ICC的分化程度和淋巴转移有关(χ2=4.15~14.61,P<0.05),但与临床分期无关(χ2=1.64~3.21,P>0.05);SLeX和CD44v6表达与E-Cad表达有关(2χ=7.87、7.58,P<0.05)。结论ICC侵袭转移过程中,SLeX、CD44v6和E-Cad表达可能具有正、负协同效应,联合检测三者表达可作为判断ICC预后的参考指标。
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| 关 键 词： | 宫颈肿瘤 肿瘤转移 唾液酸化路易斯-X抗原 CD44v6 E-钙黏附素 免疫组织化学 |
EXPRESSIONS AND CLINICAL SIGNIFICANCE OF SIALYL LEWIS-X, CD44v6 AND E-CADHERIN IN CERVICAL CANCER |
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| GU HUA-PING.EXPRESSIONS AND CLINICAL SIGNIFICANCE OF SIALYL LEWIS-X, CD44v6 AND E-CADHERIN IN CERVICAL CANCER[J].Acta Academiae Medicinae Qingdao Universitatis,2010,46(1):10-12. |
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| Authors: | GU HUA-PING |
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| Institution: | Department of Pathology;251 PLA Hospital;Zhangjiakou 075000;China |
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| Abstract: | Objective To investigate the expression and clinical significance of adhesion molecules sialyl Lewis-X(SLeX) antigen,CD44v6 and E-cadherin(E-Cad) proteins in invasive carcinoma of cervix(ICC). Methods Immunohistochemical method was used to examine the expressions of SLeX,CD44v6 and E-Cad in 60 cases of ICC and 20 cases of chronic cervicitis(CCV),and their association with clinical pathological features were analyzed. Results In ICC,the positive expression rates of SLeX,CD44v6 and E-Cad proteins were 60.0%(3... |
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| Keywords: | uterine cervical neoplasms neoplasm metastasis sialyl Lewis-X antigen CD44v6 E-cadherin immunohistochemistry |
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