| 不稳定型心绞痛病人sCAMS与sC5b-9的变化 |
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| 引用本文： | 王立杰,王红巧.不稳定型心绞痛病人sCAMS与sC5b-9的变化[J].青岛大学医学院学报,2011,47(6):527-528,530. |
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| 作者姓名： | 王立杰 王红巧 |
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| 作者单位： | 1. 胶南市泊里中心卫生院,山东胶南,266400
2. 青岛市海慈医疗集团 |
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| 摘 要： | 目的探讨不稳定型心绞痛(UA)病人可溶性细胞黏附分子(sCAMS)与可溶性补体激活产物(sC5b-9)水平的变化及其意义。方法采用ELISA方法检测36例健康人和110例UA病人血清sCAMS、sC5b-9浓度的变化。结果 UA病人血清可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞间黏附分子-1(sVCAM-1)、sC5b-9浓度明显高于对照组,差异有极显著性(t=4.485～37.314,P<0.001);心绞痛发作时sICAM-1、sVCAM-1、sC5b-9的浓度增高较缓解后更明显(t=5.764～30.638,P<0.001);不同类型的心绞痛病人发作时和缓解后sICAM-1、sVCAM-1、sC5b-9浓度差异也有显著性(F=12.074～709.477,q=3.340～52.308,P<0.05～0.001);自发性心绞痛病人sCAMS、sC5b-9浓度增高较其他类型更明显。心绞痛发作时和缓解后,血清sC5b-9与sICAM-1、sVCAM-1浓度呈正相关(r=0.530～0.703,P<0.001)。结论 UA的发生发展与CAMS和sC5b-9浓度变化有密切关系。
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| 关 键 词： | 心绞痛 不稳定型 细胞黏附分子 补体C5b 诊断 |
CHANGES OF CELLULAR ADHESION MOLECULES AND COMPLEMENT COMPONENT IN SERUM OF PATIENTS WITH UNSTABLE ANGINA |
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| WANG Lijie,WANG Hongqiao.CHANGES OF CELLULAR ADHESION MOLECULES AND COMPLEMENT COMPONENT IN SERUM OF PATIENTS WITH UNSTABLE ANGINA[J].Acta Academiae Medicinae Qingdao Universitatis,2011,47(6):527-528,530. |
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| Authors: | WANG Lijie WANG Hongqiao |
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| Institution: | WANG Lijie,WANG Hongqiao(Department of Medicine,Poli Central Hospital of Jiaonan City,Qingdao 266400,China) |
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| Abstract: | Objective To discuss the significance of changes of the levels of soluble cellular adhesion molecules(sCAMS) and complement activation component(sC5b-9) in patients with unstable angina(UA).Methods Using enzyme-linked immunosorbent assay(ELISA),changes of serum levels of sCAMS and sC5b-9 were detected in 110 UA patients and 36 healthy people.Results Levels of soluble intercellular adhesion molecule-1(sICAM-1),soluble vascular cellular adhesion molecule-1(sVCAM-1) and sC5b-9 in UA patients were significantly... |
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| Keywords: | angina unstable cellular adhesion molecules complement C5b diagnosis |
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