| 恶性血液病患者血浆纤维蛋白原、D二聚体、抗凝血酶的变化 |
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| 引用本文： | 李萍,欧阳建,周荣富,许景艳,陈兵,杨永公,张启国,邵晓雁,关朝阳,徐勇.恶性血液病患者血浆纤维蛋白原、D二聚体、抗凝血酶的变化[J].血栓与止血学,2010(1):24-26. |
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| 作者姓名： | 李萍 欧阳建 周荣富 许景艳 陈兵 杨永公 张启国 邵晓雁 关朝阳 徐勇 |
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| 作者单位： | 南京大学医学院附属鼓楼医院血液科,南京,210008 |
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| 摘 要： | 目的探讨血液肿瘤患者血浆纤维蛋白原（Fbg）、D-二聚体（D—D）、抗凝血酶（AT）活性变化及其临床意义。方法应用t检验回顾性分析50例血液肿瘤患者初发、缓解、部分缓解、复发时Fbg、D-D、AT活性水平的差异。结果缓解组、未缓解组、复发组Fbg水平较对照组降低，复发组Fbg水平较缓解组降低，具有显著性差异（P〈0．05）。复发组D-D水平较对照组、缓解组及部分缓解组升高，差异具有显著性（P〈0．05）。初发组、缓解组、未缓解组、复发组较对照组AT活性显著降低（P〈0．05）；复发组AT活性较对照组及缓解组降低，具有显著性差异（P〈0．05）。结论通过测定Fbg、D—D、AT活性，可评估血液病患者凝血功能，同时可作为判断患者病情变化及预后的一项指标。
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| 关 键 词： | 恶性血液病 纤维蛋白原 D二聚体 抗凝血酶 |
The Changes of Plasma Fibrinogen,D-dimer and Antithrombin Levels in Patients with Hematological Malignancy |
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| LI Ping,OU Yang-jian,ZHOU Rong-fu,XU Jing-yan,CHEN Bing,YANG Yong-gong,ZHANG Qi-guo,SHAO Xiao-yan,GUAN Chao-yang,XU Yong.The Changes of Plasma Fibrinogen,D-dimer and Antithrombin Levels in Patients with Hematological Malignancy[J].Chinese Journal of Thrombosis and Hemostasis,2010(1):24-26. |
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| Authors: | LI Ping OU Yang-jian ZHOU Rong-fu XU Jing-yan CHEN Bing YANG Yong-gong ZHANG Qi-guo SHAO Xiao-yan GUAN Chao-yang XU Yong |
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| Institution: | LI Ping,OU Yang-jian,ZHOU Rong-fu,XU Jing-yan,CHEN Bing,YANG Yong-geng,ZHANG Qi-guo,SHAO Xiao-yan,GUAN Chao-yang,XU Yong (Department of Hematology,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,210008,China) |
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| Abstract: | Objective To assess the clinical value of fibrinogen(Fbg),D-dimer(D-D) and antithrombin (AT) for leukemia,lymphoma and multiple myeloma patients.Methods 50 hematological malignancy patients were divided into newly-diagnosed group,CR(complete remission) group,PR(partial remission) group and PD(progression of disease) group.Clinical data of Fbg,D-D and AT were analyzed retrospectively for these group and normal control group.Results Fbg of CR,PR and PD group were lower than control group.Compared with CR grou... |
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| Keywords: | Hematological malignancy Fibrinogen D-dimer Antithrombin |
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