原发性肾病综合征患者血栓前状态的研究

目的探讨原发性肾病综合征患者血栓前状态指标：血浆血管性血友病因子（vWF）、D二聚体、纤维蛋白原、抗凝血酶水平的变化及其临床意义。方法用法国产STA-R全自动血凝检测仪检测原发性肾病综合征组和正常对照组血浆vWF、D二聚体、纤维蛋白原、抗凝血酶水平。结果原发性肾病综合征患者血浆vwF、D-二聚体、纤维蛋白原水平显著高于对照组（P〈0．01），而抗凝血酶Ⅲ水平低于对照组（P〈0．05）。结论血浆vWF、D二聚体、纤维蛋白原水平升高与原发性肾病综合征患者血液高凝状态及血栓形成有一定关系。

The Study of Prethrombotic State in Patients with Primary Nephrotic Syndrome

Objective To study the changes and clinical significance of plasma von willebrand factor （ vWF）, D- dimer, fibrinogen （Fbg） and antithrombase （AT） in patients with primary nephrotic syndrome. Methods STA-R instrument made in France was used to detect the plasma levels of vWF, D-dimer, Fbg and AT. Results The levels of plasma vWF, D-dimer, Fbg in patients with primary nephrotic syndrome were significantly higher than that in the control group（P 〈 0. 01 ） , while the level of AT was lower than that in the control group（P 〈 0. 05）. Conclusion The increased levels of plasma vWF, D- dimer, Fbg maybe have relations with hyper- coagulations state and thrombosis of patients with primary nephrotic syndrome.