| 前列腺素E1脂微球载体制剂减轻大鼠肝脏缺血再灌注损伤 |
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| 引用本文： | 林海岳,张成德,文定军,杨登峰.前列腺素E1脂微球载体制剂减轻大鼠肝脏缺血再灌注损伤[J].中日友好医院学报,2006,20(6):352-354. |
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| 作者姓名： | 林海岳 张成德 文定军 杨登峰 |
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| 作者单位： | 1. 湖南省岳阳市第一人民医院,器官移植科,岳阳,414000
2. 天津市第一中心医院,移植外科,天津,300192 |
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| 摘 要： | 目的：探讨前列腺素E1脂微球载体制剂（Lipo—PGE1）对大鼠肝脏缺血再灌注损伤的保护作用。方法：制作大鼠肝脏部分缺血再灌注模型，观察Lipo—PGE1对肝脏缺血再灌注损伤大鼠肝脏中超过氧化物歧化酶（SOD）、丙二醛（MDA）和血清中谷丙转氨酶、谷草转氨酶和乳酸脱氢酶含量变化的影响。并取肝脏组织作病理检查。结果：与对照组相比，Lipo—PGE1治疗组可提高缺血再灌注损伤大鼠肝脏中SOD活力；降低再灌注肝组织中MDA含量；明显改善肝功能；肝脏病理检查肝组织损伤减轻。结论：Lipo-PGE1对大鼠肝脏缺血再灌注损伤具有保护作用。
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| 关 键 词： | 肝缺血 再灌注 前列腺素E1脂微球载体制剂 大鼠 |
| 文章编号： | 1001-0025(2006)06-0352-03 |
| 收稿时间： | 03 31 2006 12:00AM |
| 修稿时间： | 06 20 2006 12:00AM |
Protective effect of lipo-PGE1 against hepatic ischemia reperfusion injury in rats |
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| LIN Hai-yue, ZHANG Cheng-de,WEN Ding-jun,et al.Protective effect of lipo-PGE1 against hepatic ischemia reperfusion injury in rats[J].Journal of China-Japan Friendship Hospital,2006,20(6):352-354. |
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| Authors: | LIN Hai-yue ZHANG Cheng-de WEN Ding-jun |
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| Abstract: | Objective:To observe whether Lipo-PGE1 provides protective effect on the hepatic ischemic-reperfusion injure.Methods:Hepatic warm ischemia/reperfusion was performed in rats.Lipo-PGE1 was used in hepatic ischemia-reperfusion models while in control group saline was given.The hepatocellular injury,oxidative stress associated with hepatic ischemia/reperfusion injury were assayed.In addition,the hepatic histology was evaluated after the ischemia-reperfusion injure.Results:Compared to the control group,Lipo-PGE1 treated group had significantly lower malondiadehyde,significantly higher superoxide dismutase,and better hepatic function.The pathological changes of injured liver were less than those of control group.Conclusion:Lipo-PGE1 attenuates hepatic warm ischemia/reperfusion injury in rats. |
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| Keywords: | hepatic ischemia reperfusion lipo prostaglandin E1 rats |
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