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大鼠急性酒精性肝损伤模型分析
引用本文:赵静波,王泰龄.大鼠急性酒精性肝损伤模型分析[J].中日友好医院学报,1996,10(1):17-19,F002.
作者姓名:赵静波  王泰龄
摘    要:采用白酒灌胃和腹腔内注射两种酒途径复制酒精性肝损伤大鼠模型,比较两者间肝功能改变及肝组织学改变特点。结果表明,白酒灌胃制作模型优于腹腔内注射。表现为肝功能改变明显,在肝内可以形成与人类似的病变如肝细胞脂变、糖原明显减少、多数坏死灶形成伴 中性粒细胞浸润等。此外,本模型符合人的饮酒途径且制作方便,还可避免腹腔脏器粘连、感染和腹水形成等特点。认为复制争性酒精性损伤大鼠模型以白酒灌胃途径为佳。

关 键 词:大鼠  脂肪肝  酒精性  疾病模型

RAT MODEL OF ACUTE ALCOHOLIC LIVER INJURY
Zhao Jinbo,Wang Tailing,Zhang Jing,et al.RAT MODEL OF ACUTE ALCOHOLIC LIVER INJURY[J].Journal of China-Japan Friendship Hospital,1996,10(1):17-19,F002.
Authors:Zhao Jinbo  Wang Tailing  Zhang Jing  
Institution:Zhao Jinbo;Wang Tailing;Zhang Jing;et al 1996;10(1):17(Department of Pathology)
Abstract:Fifty six clegree spirit was gave intragastrically(ig)or 18%(v/v)alcohol was injected intraperitoneally(ip)to make rat model of acute alcohol liver injury,and the char-acteristics of liver function and histologic changes of these models were compared with each other.The results showed that ig model was much better than ip model.The former showed obvious abnormal liver functionl formed similar pathologic changes with that of hu-man liver,such as,fatty degeneration,a lot of necrotic foci with neutrophil infiltration and markedy glucagon lost.The ig model was easy to be made and could avoid Some shortcom-ings,such as abdominal adhesion,infection and ascites formation,etc.It is suggested that giving spint ig was better than injecting alcohol ip for making rat model of acute alcohol liver injury.
Keywords:rats  fatty liver  alcoholic  models
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