国产药物洗脱支架在急性冠脉综合征中的应用

目的：探讨国产药物洗脱支架（Firebird支架）在急性冠脉综合征急诊介入治疗中应用的安全性和有效性.方法：2004年10月～2005年7月间治疗急性冠脉综合征患者86例,所有患者均于发病12h内行急诊经皮冠状动脉介入治疗（PCI）.治疗时随机置入Firebird支架或Cypher支架.Firebird支架组46例,Cypher支架组40例.结果：86例患者急诊PCI治疗均获得成功.Firebird组46支罪犯血管置入53枚Firebird支架,Cypher组40支罪犯血管置入49枚Cypher支架.其中1例置入Cypher支架者术后出现脑出血而死亡.Firebird支架组和Cypher支架组比较,PCI术后TIMI3级率和并发症发生率无显著性差异.对85例患者进行了3～6个月的随访,两组患者均未发生任何心血管事件,术后6个月Firebird支架组有20例（43%）行冠状动脉造影检查,无一例发生支架内再狭窄;Gypher支架组有19例（49%）行冠状动脉造影检查,1例发生支架内再狭窄,两组再狭窄率无显著性差异.结论：Firebird支架在急性冠脉综合征急诊介入治疗中应用有较好的安全性和有效性.

Application of domestic drug-eluting stent in the emergency intervention of acute coronary syndrome

Objective:To investigate the safety and efficacy and therapeutic effect of domestic drug-eluting stent(Firebird stent) in the emergency intervention of acute coronary syndrome(ACS).Methods:From Oct.2004 to Jul.2005,a total of 86 patients with ACS were randomly enrolled into two groups:Cypher drug-eluting stent group(40 patients),and Firebird drug-eluting stent group(46 patients).All patients received emergency percutaneous coronary intervention(PCI) within 12 hours from the beginning of the heart attack.Results: Emergency PCI in all patients was accomplished successfully.53 Firebird stents were implanted into 46 crime lesions in the Firebird stent group while 49 Cypher stents were implanted into 40 crime lesions in the Cypher stent group.One patient in the Cypher group had cerebral hemorrhage after procedure and died three days later.There was no significant difference between two groups on the instant angiographic and clinical outcomes.At three to six months follow-up,no major adverse cardiac event(MACE) happened in all of the 85 discharged patients.On six months after PCI,20 patients received coronary angiography(CAG) in the Firebird group,with 43% of CAG rate,and no restenosis occurred in these patients.Similarly,19 patients received coronary angiography in the Cypher group,with 48% of CAG rate,in which 1 case had restenosis.The rate of restenosis had no significant difference between the two groups.Conclusion:Implantation of Firebird drug-eluting stent was safe and effective in the emergency intervention of ACS patients.