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乙型肝炎肝内ICAM-1和HLA-A,B,C表达的研究
引用本文:张绪清,张瑞,顾长海,王宇明.乙型肝炎肝内ICAM-1和HLA-A,B,C表达的研究[J].第三军医大学学报,2001,23(7):841-843.
作者姓名:张绪清  张瑞  顾长海  王宇明
作者单位:第三军医大学附属西南医院全军感染病研究所,
摘    要:目的 研究乙型病毒性肝炎肝内ICAM-1和HLA-A,B,C表达间的关系及其在乙型肝炎免疫发病机制中的作用。方法 用免疫组化单种染色检测11例正常人和70例HBV感染者肝内ICAM-1、HLA-A,B,C表达水平,并用免疫组化双重染色检测其肝内ICAM-1和HLA-A,B,C复合表达。结果 乙型肝炎患者肝细胞ICAM-1表达水平与HLA-A,B,C表达水平之间呈显著正相关(P<0.05);在炎症坏死区,表达ICAM-1的肝细胞多数也同时表达HLA-A,B,C。结论 ICAM-1和HLA-A,B,C共同参与介导乙型肝炎肝细胸的免疫损伤过程;ICAM-1/HLA-A,B,C双阳性肝细胞可能是CTL发挥有效细胞毒作用的靶细胞。

关 键 词:细胞间粘附分子-1  人白细胞抗原  乙型肝炎
文章编号:1000-5404(2001)07-0841-03
修稿时间:2000年9月30日

Study on the expression of ICAM-1 and HLA-A,B,C in the liver of viral hepatitis B
ZHANG Xu qing,ZHANG Rui,GU Chang hai,WANG Yu ming.Study on the expression of ICAM-1 and HLA-A,B,C in the liver of viral hepatitis B[J].Acta Academiae Medicinae Militaris Tertiae,2001,23(7):841-843.
Authors:ZHANG Xu qing  ZHANG Rui  GU Chang hai  WANG Yu ming
Abstract:Objective To study the relationship between intercellular adhesion molecule 1 (ICAM 1) and HLA A,B,C expression in the liver tissue of viral hepatitis B, and their role in the immunopathogenesis of viral hepatitis B. Methods The expression of ICAM 1 and HLA A,B,C in the livers of 11 healthy subjects and 70 HBV patients were detected by immunhistochemical single staining technique. The complex expression of ICAM 1 and HLA A, B, C was detected by immunhistochemical double staining technique. Results There were significant positive relation between the levels of ICAM 1 expression and the levels of HLA A,B,C expression in hepatocytes of the patients with viral hepatitis B ( P <0.05). In the areas of inflammation and necrosis, most hepatocytes expressed ICAM 1 and HLA A,B,C simultaneously. Conclusion ICAM 1 is involved in mediating immune damage of hepatocytes together with HLA A,B,C in viral hepatitis B. ICAM 1/HLA A,B,C double positive hepatocytes may be the target cells attacked by the cytotoxic T lymphocyte(CTL).
Keywords:intercellular adhesion molecule  1  human leukocyte antigen  viral hepatitis B
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