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正常人头皮毛囊角蛋白的免疫组化研究
引用本文:钟白玉,程波,麦跃,刁庆春,尹锐.正常人头皮毛囊角蛋白的免疫组化研究[J].第三军医大学学报,2000,22(11):1087-1089.
作者姓名:钟白玉  程波  麦跃  刁庆春  尹锐
作者单位:第三军医大学附属西南医院皮肤科,重庆,400038
基金项目:国家自然科学基金资助项目 !(39970 683)
摘    要:目的 了解毛发角蛋白家族在正常人头皮毛囊中的分布情况。方法 采用免疫组化染色方法对毛发角蛋白家族在正常人头皮毛囊切片上进行检测,同时比较了冰冻切片与石蜡切片(含抗原热修复)上的检测差异。结果 RCK102(K5、K8)在皮脂腺、汗腺、毛干、内外根鞘中阳性,LPIK(K7)在皮脂腺、汗腺、内根鞘中阳性。RKSE60(K10)在汗腺表达,RCK107(K14)在基底层阳性。冰冻切片及石蜡切片抗原热修复

关 键 词:头皮毛囊  角蛋白  免疫组化  正常人  冰冻切片

Study on the distribution of hair keratin in normal hair follicles by immunohistochemical staining
ZHONG Bai-yu,CHENG Bo,MAI Yue,DIAO Qing-chun,YIN Rui.Study on the distribution of hair keratin in normal hair follicles by immunohistochemical staining[J].Acta Academiae Medicinae Militaris Tertiae,2000,22(11):1087-1089.
Authors:ZHONG Bai-yu  CHENG Bo  MAI Yue  DIAO Qing-chun  YIN Rui
Abstract:Objective To study the distribution of the hair keratin family in normal scalp hair follicles. Methods The expression of hair keratin family in normal scalp hair follicles were detected by immunohistochemical methods. The difference in cryosections and paraffin embeded sections (including antigen microwave restoration) were compared. Results Positive stain in RCK102 (K5,K8) was showed in sebaceous gland, sweat gland, hair shaft and inner, outer root sheath; LP1K (K7) in sebaceous gland, sweat gland and inner root sheath; RKSE60 (K10) in sebaceous gland; RCK107(K14) in the basal layer. The positive stain in cryosections and paraffin embeded sections with antigen microwave restoration was superior to that in simple paraffin embeded sections. Conclusion The distribution of hair keratin family in hair follicle is varied, and according to the difference, the origin of hair neoplasm can be identified.
Keywords:hair follicles  keratin  immunohistochemis
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