| 福辛普利对糖尿病大鼠胰腺组织氧化应激的影响 |
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| 引用本文： | 闫纪强,刘东方,周厚地,徐鑫.福辛普利对糖尿病大鼠胰腺组织氧化应激的影响[J].第三军医大学学报,2009,31(2). |
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| 作者姓名： | 闫纪强 刘东方 周厚地 徐鑫 |
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| 作者单位： | 重庆医科大学附属第二医院内分泌科,重庆,400010 |
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| 摘 要： | 目的 研究糖尿病大鼠胰腺绀织氧化应激的情况及福辛普利干预后胰岛功能及胰腺组织的免疫组化改变.方法 21只大鼠分对照组、糖尿病组、福辛普利干预组,糖尿病组用高脂进行喂养制作糖尿病模型,干预组喂以福辛普利(5 mg/kg),在病程小同时点测定血糖、体质量及胰腺组织中硝基酪氨酸的含量,并观察胰腺组织免疫组化改变.结果 糖尿病组0与正常对照组胰腺硝基酪氨酸含量比较明显增高(P＜0.01);福辛普利干预组与糖尿病组胰腺中硝基酪氨酸含量比较明显降低,氧化应激水平亦降低(P＜0.05).结论 精尿病大鼠胰腺组织的氧化应激存在异常,福辛普利时糖尿病大鼠胰腺氧化应激存在抑制作用.
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| 关 键 词： | 糖尿病 硝基酪氨酸 福辛普利 |
Effect of Fosinopril on oxidative stress of pancreatic tissue in diabetic rats |
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| YAN Ji-qiang,LIU Dong-fang,ZHOU Hou-di,XU Xin.Effect of Fosinopril on oxidative stress of pancreatic tissue in diabetic rats[J].Acta Academiae Medicinae Militaris Tertiae,2009,31(2). |
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| Authors: | YAN Ji-qiang LIU Dong-fang ZHOU Hou-di XU Xin |
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| Institution: | YAN Ji-qiang,LIU Dong-fang,ZHOU Hou-di,XU Xin(Department of Endocrinology,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China) |
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| Abstract: | Objective To study the oxidative stress in diabetic rat pancreas,and the changes of islet function after intervention of Fosinopril.Methods Wistar rats were randomly divided into control group,diabetes group and Fosinopril treated group.The diabetes was induced by feeding the rats from diabetes group and Fosinopril group with high fat diet for 3 weeks and then once intraperitoneal injection of STZ(35 mg/kg),while additionally Fosinopril(5 mg/kg) was given to the diabetic rats in Fosinopril treated group.Blo... |
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| Keywords: | diabetes mellitus nitrotyrosine Fosinopril |
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