| 异黄酮类化合物F11抗癌活性的实验研究 |
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| 引用本文： | 张丽龙,艾国平,粟永萍,程天民,郑虎,翁玲玲.异黄酮类化合物F11抗癌活性的实验研究[J].第三军医大学学报,2007,29(12):1155-1157. |
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| 作者姓名： | 张丽龙 艾国平 粟永萍 程天民 郑虎 翁玲玲 |
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| 作者单位： | 1. 第三军医大学军事预防医学院防原医学教研室,全军复合伤研究所,创伤、烧伤与复合伤国家重点实验室,重庆,400038
2. 四川大学华西药学院药物化学教研室,成都,610041 |
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| 摘 要： | 目的 研究经结构修饰后的异黄酮类化合物F11是否具较好的体外、体内抗癌活性.方法 采用MTT法,以5,7,4'-三羟基异黄酮(genistein, GEN)作为对照,研究化合物F11对Hela细胞的抗增殖作用;采用荷瘤裸鼠模型,以GEN和环磷酰胺作为对照,研究化合物F11在体抗癌效应.结果 MTT实验结果显示,在相同的作用浓度下,F11处理组Hela细胞形态异常改变,死细胞明显增多,细胞存活率显著低于GEN作用组(P＜0.05).荷瘤动物实验结果表明与GEN相比,F11对Hela细胞裸鼠移植瘤的生长有显著的抑制作用(P＜0.01),效果与环磷酰胺相当,且未观察到毒副反应.结论 异黄酮类化合物经过特定结构修饰,可显著增强其抗癌效应,有值得进一步研究开发的潜在价值.
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| 关 键 词： | 异黄酮 裸鼠 |
| 文章编号： | 1000-5404（2007）12-1155-03 |
| 修稿时间： | 2007-03-22 |
On anticancer activity of isoflavone derivative F11 |
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| ZHANG Li-long,AI Guo-ping,SU Yong-ping,CHENG Tian-min,ZHENG Hu,WENG Ling-ling.On anticancer activity of isoflavone derivative F11[J].Acta Academiae Medicinae Militaris Tertiae,2007,29(12):1155-1157. |
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| Authors: | ZHANG Li-long AI Guo-ping SU Yong-ping CHENG Tian-min ZHENG Hu WENG Ling-ling |
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| Institution: | IState Key Laboratory of Trauma, Bums and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038; 2West China School of Pharmacy, Sichuan University, Chengdu 610041, China |
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| Abstract: | Objective To investigate whether structurally modified isoflavone derivatives have better antitumor activity in vivo and in vitro.Methods The antiproliferative activity of compound F11 against Hela strain cells was analyzed by MTT and compared with that of Genistein.The nude mouse loading Hela tumor cells was used to evaluate the in vivo antitumor activity of F11 and the results were compared with that of Genistein and Cytoxan.Results Compound F11 had better performance than Genistein in antitumor tests as revealed by in vitro MTT measurement and in vivo nude mice model loading Hela tumor cells.Conclusion Isoflavone derivatives could be modified to acquire potent cytotoxicity on tumor cells,which are of potential clinical value and worth further investigation. |
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| Keywords: | Hela MTT |
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