| 三氧化二砷PLGA纳米粒的制备及工艺优化 |
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| 引用本文： | 张乐,周世文.三氧化二砷PLGA纳米粒的制备及工艺优化[J].第三军医大学学报,2006,28(11):1249-1251. |
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| 作者姓名： | 张乐 周世文 |
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| 作者单位： | 第三军医大学新桥医院临床药理基地,重庆,400037 |
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| 摘 要： | 目的载三氧化二砷乳酸羟基乙酸共聚物(polylactic-co-glycolic acid, PLGA)纳米粒的制备及其工艺优化.方法以PLGA为载体材料,采用w/o/w型乳化溶剂挥发法制备载As2O3纳米粒,通过均匀设计试验优化处方和制备工艺.结果在优化条件下制备的纳米粒形态圆整、大小均匀,平均粒径为178.2 nm,平均包封率为53.19%,平均载药量为0.64%.结论本纳米粒制备工艺简单,质量可控.
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| 关 键 词： | 三氧化二砷 纳米粒 乳酸羟基乙酸共聚物 均匀设计 |
| 文章编号： | 1000-5404（2006）11-1249-03 |
| 收稿时间： | 2006-01-10 |
| 修稿时间： | 2006-02-24 |
Optimizing preparation of arsenic trioxide-loaded polylactic-co-glycolic nanoparticles |
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| ZHANG Le,ZHOU Shi-wen.Optimizing preparation of arsenic trioxide-loaded polylactic-co-glycolic nanoparticles[J].Acta Academiae Medicinae Militaris Tertiae,2006,28(11):1249-1251. |
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| Authors: | ZHANG Le ZHOU Shi-wen |
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| Institution: | The Base of Clinical Pharmacology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China |
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| Abstract: | Objective To study the preparation of polylactic-co-glycolic acid(PLGA) nanoparticles carrying arsenic trioxide(As_(2)O_(3)).Methods Polymer PLGA was used to prepare arsenic trioxide nanoparticles with w/o/w double-emulsion evaporation technique,which was optimized by uniform design test.Results The shape of As_(2)O_(3)-loaded PLGA nanoparticle was round,the size was well-distributed,the mean diameter was 178.2 nm,the average encapsulation ratio reached 53.19%,and the average drug loading was 0.64%.Conclusion The technique to prepare nanoparticles is simple and the quality can be easily controlled. |
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| Keywords: | As_2O_3 nanoparticles polylactic-co-glycolic acid uniform design |
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