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放射损伤,烧伤及复合伤时肝线粒体功能障碍与脂质过氧化作用
引用本文:熊业,陈宗荣.放射损伤,烧伤及复合伤时肝线粒体功能障碍与脂质过氧化作用[J].第三军医大学学报,1991,13(5):439-442.
作者姓名:熊业  陈宗荣
作者单位:第三军医大学卫防系复合伤研究室 630038 (熊业),第三军医大学卫防系复合伤研究室 630038(陈宗荣)
摘    要:本文采用小鼠6 Gyγ射线全身照射和20%Ⅲ度凝固汽油烧伤模型,观察了伤后9 d内单伤和复合伤小鼠肝线粒体脂质过氧化物、维生素E及巯基含量、细胞色素氧化酶活力,呼吸控制率和磷氧比值的变化。结果表明脂质过氧化作用在复合伤组早期增加呈现复合效应。维生素E含量在单伤组下降更明显。巯基含量在各伤组变化总趋势是升高。细胞色素氧化酶活力在单放组第7天显著升高。呼吸控制率和磷氧比值以复合伤组下降更明显。实验结果提示伤后肝线粒体呼吸功能障碍与脂质过氧化损伤有一定关系。

关 键 词:放射损伤  烧伤  线粒体  过氧化脂类

Hepatic mitochondrial dysfunction and lipid peroxidation after and radiation-burn injuries in mice
Xiong Ye,Chen Zongrong.Hepatic mitochondrial dysfunction and lipid peroxidation after and radiation-burn injuries in mice[J].Acta Academiae Medicinae Militaris Tertiae,1991,13(5):439-442.
Authors:Xiong Ye  Chen Zongrong
Abstract:Male mice were subjected to 6 Gy total body irradiation,20% TBSA full thickness burns,or both the injuries respectively,and then lipid peroxides (LPO),vitamin E,sulfhydryl groups,respiratory control ratio (RCR),ADP/O ratio,and cytochrome oxidase activity of hepatic mitochondria were determined in the animals in the first 9 postinjury days.It was found that.1.LPO level increased in the early postinjury stage in the combined radiation-burn injury group.2.Vitamin E level decreased significantly in both the groups with either only irradiation or burns.3.The sulfhydryl groups showed a tendency to increase in all the 3 groups.4.The activity of cytochrome oxidase increased signficantly on the 7th postinjury day in the combined injury group.5.RCR and ADP/O ratios decreased more significantly in the combined injury group than in either the single injury group.These facts suggest that the suppression of the respiratory function of hepatic mitochondria results from the damage of mitochondrial membranes due to iipid peroxidation.
Keywords:radiation injury  burn injury  lipid peroxidation  antioxidant  cytochrome oxidase  mitochondrium
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