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大鼠慢性脑灌注不足脑内小胶质细胞活化和脑的病理改变
引用本文:李露斯,刘之荣.大鼠慢性脑灌注不足脑内小胶质细胞活化和脑的病理改变[J].第三军医大学学报,2001,23(4):398-400.
作者姓名:李露斯  刘之荣
作者单位:1. 第三军医大学附属西南医院神经内科,
2. 兰州军区总医院干三科,
基金项目:国家自然科学基金资助项目!( 39770 2 73)
摘    要:目的:探讨慢性脑灌注不足脑内小胶质细胞活化规律与脑病理改变的关系。方法:利用大鼠双侧颈总动脉持久性结扎所致慢性脑灌注不足的动物模型,用OX18抗MHC I类抗原和OX6抗MHC Ⅱ类抗原的免疫组化染色,观察不同脑区小胶质细胞变化规律;用光镜观察脑的病理改变。结果:慢性脑灌注不足可引起脑内小胶质细胞的活化,随着缺血时间的延长,小胶质细胞在皮层和白质的活化有所增加;缺血后脑的病理改变以神经细胞变性、固缩和退变,皮层下白质的神经纤维和髓鞘溃变为主,普遍存在胶质细胞增生,形成胶质小结。经环孢素A治疗后以上变化明显减轻。结论:慢性脑灌注不足所致脑内小胶质细胞的活化与脑内病理改变有关,免疫抑制剂环孢素A对此有一定的治疗作用。

关 键 词:慢性脑灌注不足  小胶质细胞  病理改变  环孢素A  大鼠  脑缺血
文章编号:1000-5404(2001)04-0398-03
修稿时间:2000年5月25日

Activation of microglia and pathological changes in chronically hypoperfused brain of rats
LI Lu-Si,LIU Zhi-rong.Activation of microglia and pathological changes in chronically hypoperfused brain of rats[J].Acta Academiae Medicinae Militaris Tertiae,2001,23(4):398-400.
Authors:LI Lu-Si  LIU Zhi-rong
Abstract:Objective To study the pattern of activities of microglia, the patholgical changes of chronically hypoperfused brain of rats and the interrelationship between them. Methods Model of chronically hypoperfused brain was established in rat by the ligation of both common carotid arteries, and the histopathological changes of brain were observed with light microscope. The activity of microglia of the brain were also observed with immunohistochemistry method and the number of microglia was measured with image analyzer. Results Extensive activation of microglia was observed after chronic cerebral hypoperfusion and the activation was increased with the elapse of time of hypoperfusion. There were obvious pathological change in the brain after the chronic cerebral hypoperfusion, such as myelinic degeneration and formation of glial nodule in white matter. After treated with cyclosporin A, the number of microglia was obviously reduced, but the pathological change was evidently decreased. Conclusion The activation of microglia resulted from chronic cerebral hypoperfusion is relates to the pathological changes of the brain. However, cyclosporin A can decrease the pathological change and inhibit the activation of microglia.
Keywords:chronic cerebral hypoperfusion  microglia  pathological change  cyclosporin A
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