| 糖尿病性心肌病大鼠的心肌结构,代谢和功能的变化 |
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| 引用本文： | 梁自文,张忠辉.糖尿病性心肌病大鼠的心肌结构,代谢和功能的变化[J].第三军医大学学报,1996,18(4):306-308. |
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| 作者姓名： | 梁自文 张忠辉 |
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| 作者单位： | 第三军医大学附属西南医院内分泌科 |
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| 摘 要： | 通过腹腔注射链脲佐菌素制成糖尿病大鼠模型。８周后与正常对照鼠比较血糖、血脂、心肌功能、高能磷酸含量及超微结构的改变；糖尿病鼠表现出高血糖、高血脂，左室收缩和舒张功能下降，心肌高能磷酸含量降低，心肌超微结构损害，但未伴有冠状动脉及其分枝的病变。结果表明糖尿病性心肌病的独立存在。
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| 关 键 词： | 糖尿病 心功能 高能磷酸 冠状动脉 超微结构 大鼠 |
Changes of myocardial structure, metabolism and functions in diabetic cardiomyopathy in rats |
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| Liang Ziwen,Zhang Zhonghui,Zhang Ping,Chen Yisheng.Changes of myocardial structure, metabolism and functions in diabetic cardiomyopathy in rats[J].Acta Academiae Medicinae Militaris Tertiae,1996,18(4):306-308. |
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| Authors: | Liang Ziwen Zhang Zhonghui Zhang Ping Chen Yisheng |
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| Abstract: | Eight weeks after the rats were inflicted with diabetic cardiomyopathy with intraperitoneal injection of 55 mg/kg streptozotocin, the changes of blood content of sugar and fat, myocardial functions, myocardial content of high energy phosphoric acid and myocardial ultrastructure were studied. It was found that the rats with diabetic cardiomyopathy exhibited hyperglycemia, hyperlipemia, decrease in contraction and relaxation of the left ventricle, decrease of the myocardial content of high energy phosphoric acid and damages of the myocardial ultrastructures without the involvement of the coronary arterial system. These findings confirm that the occurrence of diabetic cardiomyopathy is independent from atherosclerosis or microvascular disease. |
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| Keywords: | diabetic cardiomyopathy cardiac function coronary artery high energy phosphoric acid ultrastructure rat |
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