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重庆地区人工机械瓣膜置换术后患者VKORC1-1639A/G遗传基因多态性与华法林剂量调整的研究
引用本文:顾强,陈柏成,郝嘉,王学锋,肖颖彬.重庆地区人工机械瓣膜置换术后患者VKORC1-1639A/G遗传基因多态性与华法林剂量调整的研究[J].第三军医大学学报,2009,31(23).
作者姓名:顾强  陈柏成  郝嘉  王学锋  肖颖彬
作者单位:第三军医大学新桥医院全军心血管外科中心,重庆,400037 
摘    要:目的 探讨重庆地区人工机械瓣膜置换术后患者VKORCI-1639A/G基因多态性与华法林剂量和抗凝效果的关系.方法 采用PCR-RFLP技术对100例重庆地区汉族人工机械瓣膜置换术后抗凝治疗患者VKORC1-1639A/G多态性位点进行检测,计算其基因型和等位基因频率,同时记录患者服药期间的用药剂量.结果 100例重庆地区汉族人工机械瓣膜置换术后抗凝治疗患者中共筛选到2种等位基因:A和G.等位基因频率分别为92%和8%.,同时VKORC1-1639A/G基因多态性共检测到3种基因型,以AA基因型常见,基因型频率86%,其次为AG和GG型,分别为12%和2%.在达到抗凝指标(1.5~2.0)后,含有等基因G的患者需要的华法林维持剂量(5.27±0.55)mg]明显高于基因型为AA患者的华法林维持剂量(2.41±0.75)mg].100例重庆地区汉族人工机械瓣膜置换术后抗凝治疗患者VKORC1-1639A/G基冈多态性与相应的患者的口服剂量有相关.结论 VKORC1基因多态性与术后扰凝治疗患者华法林维持剂量有关系.

关 键 词:人工机械瓣膜置换术后  抗凝稳定状态  重庆地区  基因多态性  个体剂量差异

Effect of VKORC1-1639A/G genetic polymorphisms on warfarin dosage requirements and anticoagulation in patients with mechanical heart valve prostheses in Chongqing region
GU Qiang,CHENG Bai-cheng,HAO Jia,WANG Xue-feng,XIAO Ying-bin.Effect of VKORC1-1639A/G genetic polymorphisms on warfarin dosage requirements and anticoagulation in patients with mechanical heart valve prostheses in Chongqing region[J].Acta Academiae Medicinae Militaris Tertiae,2009,31(23).
Authors:GU Qiang  CHENG Bai-cheng  HAO Jia  WANG Xue-feng  XIAO Ying-bin
Institution:GU Qiang,CHENG Bai-cheng,HAO Jia,WANG Xue-feng,XIAO Ying-bin (Cardiovascular Surgery Center,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China)
Abstract:Objective To investigate the polymorphism of Vitamin K epoxide reductase complex subunit 1 (VKORC1-1639A/G) in patients with mechanical heart valve prostheses as well as the possible relationship between the individual warfarin dosage requirements and this genetic polymorphism in Chinese patients in Chongqing region. Methods The polymorphism of VKORC1-1639A/G in 100 patients with mechanical heart valve prostheses operated in our department from September 1987 to October 2007 was detected by using PCR-RFLP a...
Keywords:VKORC1-1639A/G  heart value prostheses  anticoagulants  Chongqing region  VKORC1-1639A/G  genetic polymorphism  individual warfarin dosage requirements
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