| 脂联素基因Gly15Gly多态性与糖尿病大血管病变的关系 |
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| 引用本文： | 艾智华,房殿春,张忠辉.脂联素基因Gly15Gly多态性与糖尿病大血管病变的关系[J].第三军医大学学报,2008,30(6):536-538. |
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| 作者姓名： | 艾智华 房殿春 张忠辉 |
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| 作者单位： | 1. 第三军医大学西南医院,全军消化病研究所,重庆,400038
2. 第三军医大学西南医院,内分泌科,重庆,400038 |
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| 摘 要： | 目的 探讨脂联素基因Gly15Gly多态性与糖尿病早期大血管病变发生的关系.方法 运用多聚酶链式反应.限制性片段长度基因多态性(PCR-RFLP法)分析方法,对56例伴大血管病变和120例无大血管病变的2型糖尿病患者脂联素基因GIy15Gly多态性位点进行基因分型.结果 大血管病变组GG基因型频率(25.0%)显著高于无血管病变组(6.2%),G等位基因频率显著升高(P<0.05);GG基因型血浆脂联素水平显著低于TT和TG基因型.结论 脂联素基因GIy15G1y多态性与糖尿病大血管并发症的发生有关,脂联素基因 45位点GG基因型是2型糖尿病大血管并发症的易感基因型.
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| 关 键 词： | 脂联素 基因多态性 糖尿病 大血管病变 |
| 文章编号： | 1000-5404(2008)06-0536-03 |
| 修稿时间： | 2008年1月9日 |
Association of adiponectin gene Gly15Gly polymorphism with primary macroangiopathy in diabetes mellitus |
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| AI Zhi-hua,FANG Dian-chun,ZHANG Zhong-hui.Association of adiponectin gene Gly15Gly polymorphism with primary macroangiopathy in diabetes mellitus[J].Acta Academiae Medicinae Militaris Tertiae,2008,30(6):536-538. |
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| Authors: | AI Zhi-hua FANG Dian-chun ZHANG Zhong-hui |
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| Institution: | 1Gastroenterology Research Center;2Department of Endocrinology;Southwest Hospital;Third Military Medical University;Chongqing 400038;China |
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| Abstract: | Objective To investigate the association adiponectin gene polymorphism with primary macroangiopathy in diabetes mellitus. Methods Type 2 diabetes mellitus (T2DM) patients were included, 56 patients complicated with atherosclerosis (AS) and 120 non-AS group. We evaluated their Gly15Gly polymorphism of adiponectin gene by PCR restriction fragment length polymorphism (PCR-RFLP). Results The AS patients were more likely to have GG genotype than the non-AS patients (25.0% vs 6.2%, P<0.05). Blood adiponectin in t... |
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| Keywords: | adiponectin gene polymorphism diabetes mellitus macroangiopathy |
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