毛细支气管炎患儿血清IL-6、IL-8、INF-γ和TNF-α水平动态变化与病情关系的研究

目的 探讨毛细支气管炎患儿血清的IL-6、IL-8、INF-γ和TNF-α水平动态变化在呼吸道合胞病毒性毛细支气管炎发病中的作用.方法 检测74例住院毛细支气管炎患儿急性期与恢复期血清的IL-6、IL-8、INF-γ和TNF-α水平,并与正常对照组进行比较.结果 患儿组急性期血清IL-6、IL-8、和TNF-α水平显著高于恢复期和对照组(P＜0.05),恢复期与健康对照组间无显著差异(P＞0.05);患儿组急性期血清INF-γ水平显著底于恢复期和对照组(P＜0.05),恢复期与健康对照组间无显著差异(P＞0.05).结论 Th1/Th2失衡致IFN-γ水平降低在毛细支气管炎发病中起重要作用;IL-6与IL-8和TNF-α可以作为预测毛细支气管炎病情的实验室指标.

Change of interleukin-6, interleukin-8, interferon gamma and TNF alpha in children with bronchiolitis

Objective To study the role of the interleukin-6,interleukin-8,TNF alpha and interferon gamma in infants with bronchiolitis induced by respiratory syncytial virus.Methods The serum levels of interleukin-6,interleukin-8,TNF alpha and interferon gamma were detected in 74 infants with bronchiolitis during acute stage and convalescence stage,and compared with those of normal control group.Results The serum levels of interleukin-6,interleukin-8 and TNF alpha during acute stage were significantly increased in comparison with those during convalescence stage(P<0.05),but no significant difference was found between those during convalescence stage and those of normal control group(P>0.05).The serum levels of interferon gamma during acute stage were significantly decreased compared with those during convalescence stage(P<0.05),but no significant difference was found between those during convalescence stage and those in normal control group(P>0.05).Conclusion The decreased level of interferon gamma resulting from the ratio of Th1 and Th2 disequilibrium plays an important role in development of bronchiolitis.The serum levels of interleukin-6,interleukin-8 and TNF alpha might be markers to predict the degree of bronchiolitis in infants.