急性胰腺炎促炎因子和抗炎因子变化的动态观察

目的：探讨促炎细胞因子和抗炎细胞因子在急性胰腺炎（AP）发病过程中动态变化的意义。方法：应用ELISA法检测48例病人血液中促炎细胞因子（TNFα、IL-1β、IL-6、IL-8）和抗炎细胞因子（IL-10、IL-1 ra)。结果：AP病人血液中促炎细胞因子和抗炎细胞因子在早期持续显著升高（与正常对照组相比P＜0.05)，其后逐渐下降，并与临床症状变化的时相一致。结论：促炎细胞因子和抗炎细胞因子的动态变化可能对急性胰腺炎的发生发展具有重要作用。

Dynamic changes of pro- and anti-inflammatory cytokines in acute pancreatitis

Objective　To explore the significance of the dynamic changes of pro-and anti-inflammatory cytokines in the onset and development of acute panreatitis (AP). Methods　Pro-inflammatory cytokines TNFα, IL-1β, IL-6, and IL-8 and anti-inflammatory cytokines IL-10 and IL-1ra in the plasma of 48 patients with AP and 20 healthy individuals were determined with ELISA. Results　The levels of all pro-and anti-inflammatory cytokines in plasma was significantly higher in AP patients than in control group (P<0.05) in early stage of the disease, and then all levels were decreased gradually, consistent with the alterations of clinical symptoms of the AP patients. Conclusion　The dynamic changes of pro-and anti-inflammatory cytokines might play important role in the onset and development of AP.