| 轻微肝性脑病患者血清中代谢物组的研究 |
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| 引用本文： | 齐素文,戴勇,欧阳昕,彭武建,蔡安季,涂植光.轻微肝性脑病患者血清中代谢物组的研究[J].第三军医大学学报,2011,33(23):2503-2507. |
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| 作者姓名： | 齐素文 戴勇 欧阳昕 彭武建 蔡安季 涂植光 |
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| 作者单位： | 1. 400016重庆,重庆医科大学教育部重点实验室,临床医学检验诊断实验室
2. 暨南大学第二临床医学院深圳市人民医院临床医学研究中心,广东深圳,510632 |
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| 摘 要： | 目的 检测轻微肝性脑病(minimal hepatic encephalopathy,MHE)患者血清中的代谢物组,初步建立MHE诊断模型.方法 采用核磁共振(NMR)方法检测25例肝硬化患者(肝硬化组)、25例轻微肝性脑病患者(MHE组)和30例健康对照(对照组)血清中的代谢物,应用主成分分析(PCA)和正交偏最小二...
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| 关 键 词： | 代谢组学 轻微肝性脑病 模式识别分析 |
Study on metabolic signature of serum in patients with mild hepatic encephalopathy |
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| Qi Suwen,Dai Yong,Ouyang Xin,Peng Wujian,Cai Anji,Tu Zhiguang.Study on metabolic signature of serum in patients with mild hepatic encephalopathy[J].Acta Academiae Medicinae Militaris Tertiae,2011,33(23):2503-2507. |
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| Authors: | Qi Suwen Dai Yong Ouyang Xin Peng Wujian Cai Anji Tu Zhiguang |
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| Institution: | Qi Suwen1,Dai Yong1,Ouyang Xin2,Peng Wujian2,Cai Anji1,Tu Zhiguang1(1Key Laboratory of Laboratory Medical Diagnostics of Ministry of Education,Chongqing Medical University,Chongqing,410006,2Center of Clinical Medicine,Second Clinical Medical College,Jinan University,Shenzhen,Guangdong Province,510632,China) |
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| Abstract: | Objective To investigate the metabonomics of serum samples from patients with mild hepatic encephalopathy(MHE) and to establish a diagnostic model for MHE.Methods Nuclear magnetic resonance spectroscopy(NMR) was applied to analyze serum metabonomics from 25 patients with simple liver cirrhosis(cirrhosis group),25 cirrhotic patients with mild hepatic encephalopathy(MHE group) and 30 healthy volunteers(control group).Principal component analysis(PCA) and orthogonal partial least-squares-discriminant analysis(... |
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| Keywords: | metabonomics mild hepatic encephalopathy pattern recognition |
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