| 茶多酚与葡萄柚提取物联合应用对变异链球菌生长、产酸的影响 |
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| 引用本文： | 黄晓晶,卢国英,刘建党,江山,雷丽珊. 茶多酚与葡萄柚提取物联合应用对变异链球菌生长、产酸的影响[J]. 第三军医大学学报, 2011, 33(1): 58-60 |
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| 作者姓名： | 黄晓晶 卢国英 刘建党 江山 雷丽珊 |
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| 作者单位： | 福建医科大学附属口腔医院牙体牙髓科; |
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| 基金项目： | 福建省医学创新课题(2009-CXB-36)~~ |
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| 摘 要： | 目的探讨茶多酚与葡萄柚提取物联合应用对变异链球菌生长、产酸的影响。方法采用棋盘稀释法测定茶多酚葡萄柚提取物混合液对变异链球菌的最低抑菌浓度(MIC)值,计算分级抑制浓度(FIC)指数来判定二者的联合效应;并测定低于MIC浓度的茶多酚葡萄柚提取物混合液对变异链球菌产酸的影响。结果茶多酚和GSE单独用药时,其MIC分别为2 mg/ml和46.88 mg/L,联用时可降低单组分的使用浓度,如茶多酚1 mg/ml联用GSE 37.5 mg/L即可达到联合应用的M IC,FIC=0.75。变异链球菌培养前后的△pH值随混合液浓度的降低而明显增加。结论茶多酚与葡萄柚提取物联合应用对变异链球菌的体外抗菌活性具有相加作用,较各自的单组分用药在更低浓度即可有效抑制变异链球菌的生长、产酸。
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| 关 键 词： | 茶多酚 葡萄柚提取物 变异链球菌 抗菌活性 棋盘法 |
Effect of combined application of tea polyphenols and grapefruit-seed extract on growth and acid production of Streptococcus mutans |
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| Huang Xiaojing,Lu Guoying,Liu Jiandang,Jiang Shan,Lei Lishan. Effect of combined application of tea polyphenols and grapefruit-seed extract on growth and acid production of Streptococcus mutans[J]. Acta Academiae Medicinae Militaris Tertiae, 2011, 33(1): 58-60 |
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| Authors: | Huang Xiaojing Lu Guoying Liu Jiandang Jiang Shan Lei Lishan |
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| Affiliation: | Huang Xiaojing,Lu Guoying,Liu Jiandang,Jiang Shan,Lei Lishan(Department of Endodontics Affiliated Hospital of Stomatology,Fujian Medical University,Fuzhou,Fujian Province,350002,China) |
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| Abstract: | Objective To investigate the effect of combined application of tea polyphenols(TPs) and grapefruit-seed extract(GSE) on the growth and acid production of Streptococcus mutans.Methods Minimal inhibitory concentration(MIC) of mixed solution of TPs and GSE on the growth of Streptococcus mutans(ATCC 25175) was measured by the checkerboard method.Fractional inhibitory concentration(FIC) was calculated accordingly to evaluate the combined effect of TPs and GSE.The effect of mixed solutions of TPs and GSE,with con... |
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| Keywords: | tea polyphenols grapefruit-seed extract streptococcus mutans antimicrobial activity checkerboard method |
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