首页 | 本学科首页   官方微博 | 高级检索  
检索        

MCT1、CD147在人胶质瘤中的表达、相关性及其与预后的关系
引用本文:王晓澍,游潮,孙晓川.MCT1、CD147在人胶质瘤中的表达、相关性及其与预后的关系[J].第三军医大学学报,2010,32(9).
作者姓名:王晓澍  游潮  孙晓川
作者单位:1. 重庆医科大学附属第一医院神经外科, 重庆,400016
2. 四川大学华西医院神经外科,成都,610041
摘    要:目的探讨单羧酸转运蛋白-1(monocarboxylate transporter-1,MCT1)和CD147在不同级别人脑胶质瘤中的表达情况及其与胶质瘤预后的关系。方法采用免疫组化S-P法检测MCT1和CD147在28例低级别胶质瘤和32例高级别胶质瘤中的表达情况;建立前瞻性队列随访观察上述胶质瘤患者术后情况,使用生存曲线和COX多因素模型进行生存预后分析。结果MCT1和CD147在人脑胶质瘤中均有高表达;在高级别胶质瘤中,两者的阳性表达率(93.8%、90.6%)和强阳性表达率(73.3%、72.4%)显著高于低级别组(两者的阳性表达率为46.4%、50%,强阳性表达率为30.8%、35.7%,P0.01,P0.05),且两者表达呈正相关(r=0.671,P0.05);MCT1和CD147表达相关生存曲线差异有统计学意义(P=0.021,P=0.001),COX分析CD147高表达对胶质瘤患者的术后生存预后具有明显影响(P=0.017)。结论MCT1和CD147与胶质瘤恶性程度有密切关系,两者的表达,尤其是CD147可作为胶质瘤预后判断的参考指标和治疗靶点。

关 键 词:单羧酸转运蛋白-1  胶质瘤  预后

Expressions of MCT1 and CD147 in human gliomas and their correlations with prognosis
Wang Xiaoshu,You Chao,Sun Xiaochuan.Expressions of MCT1 and CD147 in human gliomas and their correlations with prognosis[J].Acta Academiae Medicinae Militaris Tertiae,2010,32(9).
Authors:Wang Xiaoshu  You Chao  Sun Xiaochuan
Institution:Wang Xiaoshu1,You Chao2,Sun Xiaochuan1 (1Department of Neurosurgery,First Affiliated Hospital,Chongqing Medical University,Chongqing,400016,2Department of Neurosurgery,West China Hospital,Sichuan University,Chengdu,Sichuan Province,610041,China)
Abstract:Objective To investigate the expressions and correlation of monocarboxylate transporter-1 (MCT1) and CD147 in human gliomas,and analyzee the relationship between their expressions and prognosis.Methods Immunohistochemistry SP methods were applied to detect the expressions of MCT1 and CD147 in 28 cases of low grade gliomas and 32 cases high grade gliomas.Their expression level and correlation were analyzed statistically.Prospective cohorts were set to acquire follow-up data.Kaplan-Meier curve and Cox multi-f...
Keywords:CD147
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号