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| 贲门癌家族史阳性患者比较基因组杂交变化特征 | |
| 引用本文： | 常志伟,王立东,秦艳茹,李苹娟,郭涛,李吉林,常志军,范宗民,何欣,王苒,宋昕.贲门癌家族史阳性患者比较基因组杂交变化特征[J].第三军医大学学报,2009,31(9). |
| 作者姓名： | 常志伟 王立东 秦艳茹 李苹娟 郭涛 李吉林 常志军 范宗民 何欣 王苒 宋昕 |
| 作者单位： | 1. 河南省食管癌重点开放实验室,郑州大学第一附属医院,郑州大学基础医学院,郑州,450052 2. 林州市姚村食管癌医院病理科,河南,林州,456592 3. 林州市中心医院胸外科,河南,林州,450092 |
| 基金项目： | 国家高技术研究发展计划(863计划)，国家重点基础研究发展规划(973计划)，河南省食管癌重点开放实验室基金 |
| 摘 要： | 目的 探讨河南食管贲门癌高发区贲门癌肿瘤家族史阳性/阴性患者基因组变化特征.方法 应用比较基冈组杂交技术分析14例贲门癌家族史阳性和28例贲门癌肿瘤家族史阴性患者染色体基因组变化.结果 贲门癌家族史阳性患者DNA拷贝数扩增高于阴性(>20%)者的染色体部位为20p(FH+50%与FH-21%),5p(FH+50%与FH-18%),6q(FH+43%与FH-18%),16q(FH+36%与FH-14%);贲门癌家族史阳性患者DNA拷贝数丢失高于阴性(>20%)者为4q(FH+43%与FH-14%)(P>0.05).1q、3q、6q/p、7p、8q、13q/p、20q/p染色体部位DNA拷贝数扩增和1p、17q/p、19p染色体部位DNA拷贝数丢失在贲门癌家族史阳性和阴性患者中均超过20%(P>0.05).结论 20p、5p、6q、16q、4q、17q、18q、9p、22q可能存在与贲门癌遗传高易感性相关的关键基因;而1q/p、3q、6q/p、7p、8q、13q/p、20q/p、17q/p、19p可能存在与环境因素相关的贲门癌关键基因. |
| 关 键 词： | 贲门癌 比较基因组杂交 遗传易感性 家族史 |
Characteristics of variation in comparative genomic hybridization from gastric cardia adenocarcinoma patients with family history |
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| CHANG Zhi-wei,WANG Li-dong,QIN Yan-ru,LI Ping-juan,GUO Tao,LI Ji-ling,CHANG Zhi-jun,FAN Zong-min,HE Xin,WANG Ran,SONG Xin.Characteristics of variation in comparative genomic hybridization from gastric cardia adenocarcinoma patients with family history[J].Acta Academiae Medicinae Militaris Tertiae,2009,31(9). | |
| Authors: | CHANG Zhi-wei WANG Li-dong QIN Yan-ru LI Ping-juan GUO Tao LI Ji-ling CHANG Zhi-jun FAN Zong-min HE Xin WANG Ran SONG Xin |
| Institution: | CHANG Zhi-wei1,WANG Li-dong1,QIN Yan-ru1,LI Ping-juan1,GUO Tao1,LI Ji-ling2,CHANG Zhi-jun3,FAN Zong-min1,HE Xin1,WANG Ran1,SONG Xin1 (1Henan Key Laboratory for Esophageal Cancer Research,First Affiliated Hospital,College of Basic Medicine,Zhengzhou University,Zhengzhou 450052,2Department of Pathology,Yaocun Esophageal Cancer Hospital,Linzhou 456592,Henan Province,3Department of Thoracic Surgery,Linzhou Central Hospital,Linzhou 450092,China) |
| Abstract: | Objective To characterize the profile of chromosomal imbalances in gastric cardia adenocarcinoma (GCA) with or without family history (GCA FH+ or GCA FH-) in Linzhou, Henan province, and to provide molecular basis to identify the related genes to GCA hereditary susceptibility. MethodsComparative genomic hybridization (CGH) was used to examine 14 cases with GCA FH+ and 28 cases with GCA FH-. ResultsMore frequent DNA copy number gains were observed in GCA FH+ than in GCA FH-. Those with the frequency over 20%... |
| Keywords: | gastric cardia adenocarcinoma comparative genomic hybridization hereditary susceptibility family history |
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