正常人肌注4-二甲氨基苯酚的临床初步观察

受试者5人(4男1女,年龄32～60岁)肌注4-二甲氨基苯酚3mg/kg,30min形成变性血红蛋白浓度为25％,半峰值时间为9min,随后逐渐下降。给药后5min出现紫绀,20～60min明显和局部胀痛感。80min后头痛加剧,但能忍受。12h后出现低热,白细胞总数升高,约持续一天。第二天,有行走不便,疲劳感。局部疼痛持续一周后消失。肝肾功能和心血管系统均未见异常变化。

Preliminary Observation on 4-dimethylaminophenol Intoxication in Human Beings

4-dimethylaminophenol hydrochloride (4-DMAP) was injected intramucularly to 5 healthy individuals(4 male and 1 female) in the dose of 3 mg/kg. The mean concentration of methemoglobin (MHb) increased to 25% of the total hemoglobin in 30 minutes after injection. The HT-value was 9 minutes. 3 hours after injection, the MHb level decreased to 17% of the total hemoglobin, then it continued to decrease but in a slower rate.All the 5 individuals became cyanotic 5 minutes after injection-as the MHb level was increasing. There was obvious and localized tension pains on the site of injection 20-60 minutes after injection. All the 5 complained severe but tolerable headache 80 minutes after injection. 12 hours after injection, there was low-grade fever and elevation of white blood cell count, which returned to normal in the following day. On the second day of injection, they complained of uneasiness in walking because of the pains of the injected thigh and sense of fatigue. The pains over the injection si te subsided one week after injection. The functions of the liver, the kidneys and the cardiovascular system showed nothing abnormal.