| 西洛他唑抑制颈总动脉球囊损伤后大鼠血凝素样氧化低密度脂蛋白受体-1表达 |
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| 引用本文： | 苏华科,宋耀明,郭文昀.西洛他唑抑制颈总动脉球囊损伤后大鼠血凝素样氧化低密度脂蛋白受体-1表达[J].第三军医大学学报,2009,31(18). |
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| 作者姓名： | 苏华科 宋耀明 郭文昀 |
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| 作者单位： | 第三军医大学新桥医院心血管内科,全军心血管病研究所,重庆,400037 |
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| 摘 要： | 目的 观察大鼠颈总动脉球囊损伤后血凝素样氧化低密度脂蛋白受体-1(1ectin like oxidized low density lipo-protein receptor-1.LOX-1)的表达及西洛他唑对其表达的影响,探索西洛他唑抑制内膜增生的机制.方法 24只健康雄性SD大鼠按完全随机分组法分成假手术组、模型组、西洛他唑组(n=8).观察球囊损伤后内膜增生情况并计算内膜、中膜面积比值,检测血清MDA含量,RT-PCR法和免疫组化法分别检测各组球囊损伤后大鼠颈总动脉血管壁组织中LOX-1mRNA和蛋白的表达.结果 西洛他唑组内膜/中膜面积比值(IA/MA)、LOX-1 mRNA及蛋白表达水平、血清MDA含量显著低于模型组,差异有统计学意义(P<0.05).结论 西洛他唑可显著抑制内膜增生,抑制LOX-1表达及其介导的氧化应激,这可能是西洛他唑抑制内膜增生的机制之一.
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| 关 键 词： | 血凝素样氧化低密度脂蛋白受体-1 西洛他唑 球囊损伤 再狭窄 |
Cilostazol suppresses expression of lectin like oxidized low density lipoprotein recep- tor-1 after balloon injury in rats |
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| SU Hua-ke,SONG Yao-ming,GUO Wen-yun.Cilostazol suppresses expression of lectin like oxidized low density lipoprotein recep- tor-1 after balloon injury in rats[J].Acta Academiae Medicinae Militaris Tertiae,2009,31(18). |
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| Authors: | SU Hua-ke SONG Yao-ming GUO Wen-yun |
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| Institution: | SU Hua-ke,SONG Yao-ming,GUO Wen-yun ( Institute of Cardiovascular Disease,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China) |
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| Abstract: | Objective To explore the expression of lectin-like oxidized low-density lipoprotein receptor-1 ( LOX-1) in a rat model after balloon arterial injury and investigate the effect of cilostazol on the mRNA and protein expressions of LOX-1. Methods Twenty-four male SPF SD rats were randomly divided into 3 groups ( n =8 for each group) ,sham operation group,balloon arterial injury group and cilostazol treatment group. For the rats from balloon arterial injury group and cilostazol treatment group,the left common c... |
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| Keywords: | lectin-like oxidized low-density lipoprotein receptor-1 cilostazol balloon injury restenosis |
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