| 化学沉淀法制备纳米HAP-sol及其血液相容性研究 |
| |
| 引用本文： | 王海,王友法,李世普.化学沉淀法制备纳米HAP-sol及其血液相容性研究[J].甘肃中医学院学报,2006,23(1):47-50. |
| |
| 作者姓名： | 王海 王友法 李世普 |
| |
| 作者单位： | 武汉理工大学,湖北,武汉,430070 |
| |
| 摘 要： | 目的:研究改性后的纳米HAP粒子的血液相容性.方法:采用化学沉淀法制备纳米羟基磷灰石溶胶(HAP-sol),以聚丙烯酸纳(PAA-Na)为稳定剂.通过体外溶血试验和血淋巴细胞毒性试验(MTT法)来评价HAP-sol的血液相容性.结果:红细胞溶血率在0～3%之间,细胞毒性分级为0级或1级,纳米HAP-sol对血红细胞无溶血作用,也没有明显的细胞毒性效应.结论:以PAA-Na为稳定剂,纳米HAP-sol有良好的血液相容性,纳米HAP-sol用于静脉注射药物有一定的安全性.
|
| 关 键 词： | 纳米羟基磷灰石 化学沉淀法 稳定剂 血液相容性 |
| 文章编号： | 1003-8450（2006）01-0047-04 |
| 收稿时间： | 2005-09-23 |
| 修稿时间： | 2005年9月23日 |
Study on nano hydroxyapatite sol of hemocompatibility and preparation by chemical precipitation |
| |
| Wang Hai,Wang Youfa,Li Shipu.Study on nano hydroxyapatite sol of hemocompatibility and preparation by chemical precipitation[J].Journal of Gansu College of Traditional Chinese Medicine,2006,23(1):47-50. |
| |
| Authors: | Wang Hai Wang Youfa Li Shipu |
| |
| Institution: | Wuhan University of Technology, 430070, Wuhan ; China |
| |
| Abstract: | Objective:To study the hemocompatibility of the modified hydroxyapatite(HAP) nanoparticle.Methods:Nano hydroxyapatite sol was prepared by using chemical precipitation.Used PAA-Na as the stabilizer.Hemolytic test and lymphocyte toxicity test in vitro were conducted for evaluating the nano hydroxyapatite sol of hemocompatibility.Results:The hemolytic rate of RBC was 0 tllytic effect and prominent cytotoxicity effect toRBC.Conclusion: Used PAA-Na as the stabilizer,nano hydroxyapatite sol has good hemocompatibility.It is safe that nano hydroxyapatite sol is used as a drug via intravenous injection. |
| |
| Keywords: | nano hydroxyapatite chemical precipitation stabilizer hemoeompatibility |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
