宫颈上皮内瘤变细胞学病理学分析

目的探讨液基细胞学在宫颈上皮内瘤变诊断中的准确性。方法对我院妇科门诊1960例患者进行液基细胞学(TCT)检查,对细胞学检查阳性者进行阴道镜下取活检做病理,将细胞学与病理检验结果进行对照分析。结果TCT共检出阳性涂片208例,占10.61%,其中不典型鳞状上皮细胞(ASC-US)和不典型腺上皮细胞(AGUS)88例,占4.49%;不除外高度鳞状上皮内病变的不典型鳞状上皮细胞(ASC-H)13例,占0.66%;低度鳞状上皮内病变(LSIL)81例,占4.14%;高度鳞状上皮内病变(HSIL)23例,占1.17%;鳞状细胞癌(SCC)3例,占0.15%。对208例细胞学检查阳性者进行病理检查,细胞学检查与病理检验符合率分别为:癌100%,HISL 91.3%,LSIL54.32%,ASC-H 38.46%,ASC-US AGUS 21.59%。结论TCT敏感性和准确性较高,配合阴道镜下活检病理检验,可以提高宫颈上皮内瘤变及宫颈癌的诊断率及准确率。

CYTOLOGICAL AND PATHOLOGICAL ANALYSES OF CERVICAL INTRAEPITHELIAL NEOPLASIA

Objective To explore the accuracy of thin-prep cytology test(TCT) in diagnosing cervical intraepithelial neoplasia(CIN).Methods 1960 cases of CIN underwent TCT.The cell-positive cases received pathological detection.The cross-check analyses were made.Results TCT showed 208 cases(10.61%) were positive,which included 88 cases of atypical squamous cells(ASC) and atypical glandular epithelial cells(AGEC),13 cases of possible high-grade ASC(ASC-H),81 cases of low-grade squamous intraepithelial lesion(LSIL),23 cases of high-grade squamous intraepithelial lesion(HSIL) and 3 cases of squamous cell carcinoma(SCC).The 208 cases received pathological test.The coincidence rate of TCT and pathological test were 100% in cancer,91.3% in HSIL,54.32% in LSIL,38.46% in ASC-H and 21.59% in ASC and AGES respectively.Conclusion TCT is highly sensitive and accurate and can help to improve the diagnoses of cervical intraepithelial neoplasia and cervical cancer.