降钙素原、中性粒细胞/淋巴细胞比值与急性胰腺炎预后的关系

目的 评价降钙素原(procalcitonin,PCT)和中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)与急性胰腺炎预后的关系.方法 回顾性分析了102名急性胰腺炎患者和102名健康个体在就诊时的PCT、NLR水平以及其他临床资料,并进行了比较,分析了PCT、NLR与患者临床特征的关系.采用受试者工作特征(receiver operating characteristic,ROC)曲线法和多元logistic回归分析了PCT、NLR与急性胰腺炎患者预后的关系.结果 急性胰腺炎患者的PCT和NLR较健康个体明显增高,且与急性胰腺炎患者病情相关.PCT和NLR预测患者院内死亡的曲线下面积(area under curve,AUC)分别为0.81和0.84,多个指标联合使用时的AUC为0.96.结论 NLR和PCT均与急性胰腺炎患者的预后有关,联合使用NLR和PCT更有助于预测急性胰腺炎患者的预后.

Relationship between procalcitonin,neutrophil to lymphocyte ratio and prognosis of acute pancreatitis

Objective To investigate the relationship between procalcitonin (PCT),neutrophil to lymphocyte ratio (NLR) and prognosis of acute pancreatitis.Methods Retrospective analysis was made on the levels of PCT and NLR in 102 patients with acute pancreatitis and the same number of healthy controls who sought routine medical care in the hospital,and comparisons were made between the 2 groups.Then,the relationship between PCT/NLR levels and clinical features of the patients were analyzed.Multivariable logistic regression model and receiver operating characteristic (ROC) were used to evaluate the relationship between NLR/PCT and prognosis of acute pancreatitis.Results The levels of NLR and PCT in the patients with acute pancreatitis were significantly higher than those of the healthy individuals,and both NLR and PCT were closely associated with the patient conditions.The area under curve (AUC) for PCT and NLR were respectively 0.81 and 0.84,and the AUC in multivariable combination usage was 0.96.Conclusion Both NLR and PCT were associated with prognosis of acute pancreatitis,and the combined use of NLR and PCT would facilitate to predict the prognosis of acute pancreatitis.