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阿昔洛韦聚氰基丙烯酸正丁酯毫微粒制备工艺研究
引用本文:张志荣,田辉.阿昔洛韦聚氰基丙烯酸正丁酯毫微粒制备工艺研究[J].华西医科大学学报,1998,29(3):329-333.
作者姓名:张志荣  田辉
摘    要:为了优选粒径在100nm左右、圆整的阿昔洛韦聚氰基丙烯酸正丁酯毫微粒的制备工艺及条件,采用单因素法初选影响阿昔洛韦毫微粒的因素,以毫微粒的形态、药物包封率、毫微粒载药量为综合评价指标,采用均匀设计法精选制备条件和工艺,瘩用高效液相色谱法测定含药毫微粒中阿昔洛韦的含量。结果:确定了制备条件和工艺,制得的阿昔洛韦毫微粒圆整,算术平均径为108.5±94.8nm(n=588),载药量为18.5%,包封纺

关 键 词:阿昔洛韦  聚氰基丙烯酸酯  毫微粒  均匀设计法

Preparation of acyclovir-polybutylcyanoacrylate-nanoparticles by emulsion polymerization method]
Z Zhang,H Tian,Q He.Preparation of acyclovir-polybutylcyanoacrylate-nanoparticles by emulsion polymerization method][J].Journal of West China University of Medical Sciences,1998,29(3):329-333.
Authors:Z Zhang  H Tian  Q He
Institution:Department of Pharmaceutics, School of Pharmacy, Chengdu.
Abstract:The aim of this study was to optimize the conditions and technology of preparing acyclovir-polybutylcyanoacrylate-nanoparticles (ACV-PBCA-NP) which has the diameter of about 100 nm and the shape of a sphere. The influential factors on sphericization were observed by single factor optimization. The preparation conditions and technology were optimized by the even design method. The contents of acyclovirin in acyclovir polybutyloganoacrylate nanoparticles were determined by HPLC. The optimum conditions and technology of preparing acyclovir polybutylcyanoacrylate nanoparticles were decided and put into use. The average diameter of the ACV-PBCA-NP thus prepared was 108.5 +/- 94.8 (n = 588). Its embedding ratio was 71.8%, and drug loading was 18.5%. The results suggest that the conditions and technology of preparing ACV-PBCA-NP presented in this paper are stable and practical.
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