机械性创伤患者血清肿瘤特异性生长因子的变化及其临床意义 |
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摘 要: |
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关 键 词: | 机械性创伤 肿瘤特异性生长因子 血清 诊断 恶性肿瘤 |
Changes serum level of tumor specific growth factor and their clinical significance in mechanical trauma patients] |
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Authors: | X Zhang Y Li D Wu J Wu Q Cheng X Zeng X Liu |
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Institution: | Second Hospital, Xi'an Jiaotong University, Xi'an 710004, China. |
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Abstract: | OBJECTIVE: To investigate the post-traumatic changes in the serum level of tumor specific growth factor (TSGF) and their relationship with Injury Severity Score and to inquire into the possible mechanism and clinical significance. METHODS: Fifty patients with mechanical trauma were eligible and included. According to the standard of Injury Severity Score (ISS), the patients were divided into there groups: mild degree group, (ISS < or = 16, n = 31) severe degree group (16 < ISS < 25, n = 13) extreme severe degree group (ISS > or = 25, n = 6). The blood samples of all patients were obtained within 24 hours, and those of 25 dynamically observed patients were obtained on days 3, 5, 7, 9 and 12. RESULTS: The serum level of TSGF was significantly higher in patients with trauma in different groups (P < 0.05). The dynamical observation showed that the index demonstrated curve changes with increase in early stage and decrease later. the climax of TSGF appeared on 7 day in all 3 groups. The TSGF serum levels in extremely severe degree and severe degree groups > mild degree group on days 5, 7, 9 and 12 day (P < 0.05). CONCLUSION: TSGF has relationship with the inflammatory response and recovery of trauma. |
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