| 离子对高效液相色谱法测定抗癌药盐酸米托蒽醌注射含量 |
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| 引用本文： | 宋汉敏.离子对高效液相色谱法测定抗癌药盐酸米托蒽醌注射含量[J].华西医科大学学报,1990,21(1):39-41. |
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| 作者姓名： | 宋汉敏 |
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| 摘 要： |
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| 关 键 词： | 米托蒽醌 抗癌药 含量测定 色谱法 |
Ion-paired high performance liquid chromatographic determination of mitoxantrone hydrochloride injection |
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| C Wu,P Guo,H Song.Ion-paired high performance liquid chromatographic determination of mitoxantrone hydrochloride injection[J].Journal of West China University of Medical Sciences,1990,21(1):39-41. |
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| Authors: | C Wu P Guo H Song |
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| Abstract: | Mitoxantrone (DHAQ) is a new anti-cancer agent. The ion-pair HPLC method to determine mitoxantrone hydrochloride injection was proposed. Mitoxantrone can be separated on Zorbax-ODS column with methanol-water-formic acid (450:50:1.5) containing 3.605g SDS as mobile phase. The pH of mobile phase was adjusted to 2.7. The flow rate was 1.0 ml/min and detection was at wavelength of 254 nm, providing a detection limit of 1ng (r/n, 3:1) of DHAQ. DHAQ was determined by peak area measurement with ametantrone as internal standard. The rectilinear calibration graph in the range of 1-10 micrograms of DHAQ was obtained (r = 0.999 2). The average recovery was 99.62 +/- 2.36% (n = 10), and the results were not interfered by the other ingredients in the injection. |
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