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三七皂甙R1对HL—60细胞系体外诱导分化作用的初步研究
引用本文:徐罗玲,王伯瑶.三七皂甙R1对HL—60细胞系体外诱导分化作用的初步研究[J].华西医科大学学报,1991,22(2):124-127.
作者姓名:徐罗玲  王伯瑶
摘    要:

关 键 词:三七皂甙  HL-60  诱导分化  三七

Preliminary studies of notoginsenoside R1-induced differentiation of HL-60 cell lines in vitro]
L Xu,B Wang,J Gao.Preliminary studies of notoginsenoside R1-induced differentiation of HL-60 cell lines in vitro][J].Journal of West China University of Medical Sciences,1991,22(2):124-127.
Authors:L Xu  B Wang  J Gao
Institution:Department of Pathophysiology.
Abstract:Our experiments have proved that human promyelocytic leukemia cells (HL-60) could be induced to differentiate in vitro by notoginsenoside R1 into mature neutrophils. The morphological results showed that 68% of HL-60 cells were differentiated in 80 microgram/ml inducer for 5 days, in which metamyelocytes were 32%, banded neutrophils 30% and segmented neutrophils 6% 3H-TdR and 3H-UR incorporate assay showed that notoginsenoside R1 effected synthesis of DNA and RNA while it induced differentiation of HL-60 cell. At 48 h, percent of incorporate inhibition was 26.32% with 3H-TdR and 18.57% with 3H-UR; at 72 h, 17.46% and 21.76%, respectively.
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