The photostability of hydrocortisone injection] |
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Authors: | T Lin K Li C Li C Qiu X Zhan |
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Institution: | School of Pharmacy, WCUMS, Chengdu 610041, China. |
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Abstract: | OBJECTIVE: This experiment was designed to make known wether the photostability of drugs in daylight can be obtained from lamplight exposure. METHODS: A self made cumulative illuminometer via pulse counting method was used for measuring cumulative illuminance of daylight to investige the photodegradation of Hydrocortisone injection in various lamp light and daylight; the equivalent influences of different light sources on the photostability of the injection were obtained, and the shelf-life in indoor daylight of the drug was predicted. RESULTS: The photodegradation of Hydrocortisone injection obeys zero order kinetics: C = C0-kEt; the shelf-life in indoor daylight of the injection in nude ampoules was predicted as 36 days and is comparable to 35 days in a long-term storage test. CONCLUSION: The photostability of drugs in daylight can be obtained from lamplight exposure experiment. |
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