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大鼠侧位液压冲击脑损伤动物模型的建立及病理学改变
引用本文:张永亮,汪秉康.大鼠侧位液压冲击脑损伤动物模型的建立及病理学改变[J].华西医科大学学报,1999,30(4):363-367.
作者姓名:张永亮  汪秉康
作者单位:[1]武警医学院 [2]华西医科大学法医学院法医病理学教研室
摘    要:为了能够精确地建立轻、中、重液压冲击分级脑损伤动物模型,我们设计了侧位液压冲击脑损伤装置。该装置由不锈钢储液管、压缩空气、减压设备及计算机等组成,可以精确地控制冲击气压的大小、记录冲击时脑组织所承受的压力、显示压力曲线、液压冲击后可以迅速释放系统内的压力,国内、外均未见报道。侧位液压冲击脑损伤随冲击压力的增加而加重,以冲击侧大脑半球为最重,也可波及对侧及脑底部。

关 键 词:脑损伤  侧位液压冲击  动物模型  病理学

The establishment of a modified lateral fluid percussion model of brain injury in rat and the pertinent pathologic changes]
Y Zhang,B Wang,Z Liao,J Xin,J Wu,M Wu.The establishment of a modified lateral fluid percussion model of brain injury in rat and the pertinent pathologic changes][J].Journal of West China University of Medical Sciences,1999,30(4):363-367.
Authors:Y Zhang  B Wang  Z Liao  J Xin  J Wu  M Wu
Institution:Department of Forensic Pathology, WCUMS, Chengdu 610041.
Abstract:For the purpose of studying the molecular mechanism of the traumatic brain injury, we have established a reproducible graded lateral fluid percussion model of experimental brain injury in the rat with a modified fluid percussion device. The device consists of a stainless steel cylindrical reservoir instead of the plexiglass reservoir, a steel reservoir filled with compressed gas instead of the pendulum for making more accurate percussion pressure, an apparatus for releasing the pressure immediately after the percussion, and a computer for recording and storing the percussion data. Pathologic examination demonstrated subdural hemorrhage, subarachnoid hemorrhage, and hemorrhage in the lateral ventricle and corpus callosum on the percussion side. The severity of pathologic changes increased with the magnitude of percussion. The results indicate that the new device could inflict reproducible graded lateral fluid percussion brain injury on rats and the model can be used for the studies of neuropathologic and molecular mechanism of brain injury.
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