| 鼻咽癌染色体端粒长度变化的研究 |
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| 引用本文： | 肖林,刘永惠.鼻咽癌染色体端粒长度变化的研究[J].华西医科大学学报,1999,30(3):262-264. |
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| 作者姓名： | 肖林 刘永惠 |
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| 作者单位： | [1]华西医科大学附属第一医院肿瘤中心肿瘤研究所 [2]附属第一医院耳鼻咽侯科 |
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| 摘 要： | 为探讨人自咽癌染色体端行为民癌变的关系，应用Ｓｏｕｔｈｅｒｎ印迹杂交对３０例鼻咽癌和３０例与之年龄、性别配对的正常对照进行了分析，结果：鼻咽癌的端粒长度与对照上比显著缩短。在自咽癌中，１６．１７％显示端粒伸长，７６．６７％显示端粒缩短，而６．６７％显示与对照相同的端粒长度。分析了３０例正常人外周血淋巴细胞端粒长度的变化，可见染色体端粒的长度随年龄而逐渐缩短（ｒ＝－０．３９１３，Ｐ〈０．０５），并且
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| 关 键 词： | 鼻咽肿瘤 染色体 端粒 端粒长度 |
Changes of telomere length in human nasopharyngeal carcinoma] |
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| L Xiao,H Zhou,J Yan,Y Liu,Y Song.Changes of telomere length in human nasopharyngeal carcinoma][J].Journal of West China University of Medical Sciences,1999,30(3):262-264. |
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| Authors: | L Xiao H Zhou J Yan Y Liu Y Song |
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| Institution: | Cancer Center, Cancer Research Institute, First Affiliated Hospital, WCUMS, Chengdu, 610041. |
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| Abstract: | Using Southern hybridization, we analysed the telomere length from thirty patients with nasopharyngeal carcinoma and demonstrated telomere reduction in these individuals when compared with their age-matched controls. Of the 30 samples, 16.67% had telomere elongation, 76.67% had telomere reduction and 6.67% exhibited equal lengths as compared with the controls. Analysis of leukocytes from 30 controls indicated that the telomere length decreased (average 39 base Pairs Per year) with aging and a statistically significant correlation between the length and age was noted (r = -0.3913, P < 0.05). These results suggest that the consequences of telomere shortening in nasopharyngeal carcinoma may lead to chromosome instability. |
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