人乳腺浸润性导管癌裸鼠移植模型的建立

将１９９６年１月获得的１例乳腺浸润性导管癌患者的原发肿瘤和转移淋巴结，移植于ＢＡＬＢ／ｃ－ｎｕ／ｎｕ裸小鼠胸部乳垫下，３１天后局部出现肿瘤结节，并逐渐长大，以后进行鼠间传代移植，现已１５代，移植成功率１００％，肿瘤保持了原先的生物学特性，经医学文献检索证实，该模型在国内属首次建立，为乳腺癌的深入研究建立了有一个很有价值的模型。

Establishment of a heterologous graft model for human breast infiltrating duct carcinoma in nude mice]

A heterologous graft model for human breast infiltrating duct carcinoma is reported in this paper. The grafts derived from an infiltration duct carcinoma of a patient's right breast and her metastatic lymphnode mass were transplanted into the breast pads of nude mice in 1996, and the carcinoma masses were found in breast pads 31 days later. By now, the grafts of carcinoma have been transplanted into nude mice for 15 passages with a full success in 59 mice and with the biological characteristics of the original breast carcinoma. This heterologous graft model was established for the first time in China and the results suggest it be a good model for further research of breast carcinoma.